Cargando…
Yueju Pill Rapidly Induces Antidepressant-Like Effects and Acutely Enhances BDNF Expression in Mouse Brain
The traditional antidepressants have a major disadvantage in delayed onset of efficacy, and the emerging fast-acting antidepressant ketamine has adverse behavioral and neurotoxic effects. Yueju pill, an herb medicine formulated eight hundred years ago by Doctor Zhu Danxi, has been popularly prescrib...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654702/ https://www.ncbi.nlm.nih.gov/pubmed/23710213 http://dx.doi.org/10.1155/2013/184367 |
_version_ | 1782476063637504000 |
---|---|
author | Xue, Wenda Zhou, Xin Yi, Nan Jiang, Lihua Tao, Weiwei Wu, Runjie Wang, Dan Jiang, Jingjing Ge, Xiaoyin Wang, Yuyue Wu, Haoxin Chen, Gang |
author_facet | Xue, Wenda Zhou, Xin Yi, Nan Jiang, Lihua Tao, Weiwei Wu, Runjie Wang, Dan Jiang, Jingjing Ge, Xiaoyin Wang, Yuyue Wu, Haoxin Chen, Gang |
author_sort | Xue, Wenda |
collection | PubMed |
description | The traditional antidepressants have a major disadvantage in delayed onset of efficacy, and the emerging fast-acting antidepressant ketamine has adverse behavioral and neurotoxic effects. Yueju pill, an herb medicine formulated eight hundred years ago by Doctor Zhu Danxi, has been popularly prescribed in China for alleviation of depression-like symptoms. Although several clinical outcome studies reported the relative short onset of antidepressant effects of Yueju, this has not been scientifically investigated. We, therefore, examined the rapid antidepressant effect of Yueju in mice and tested the underlying molecular mechanisms. We found that acute administration of ethanol extract of Yueju rapidly attenuated depressive-like symptoms in learned helpless paradigm, and the antidepressant-like effects were sustained for at least 24 hours in tail suspension test in ICR mice. Additionally, Yueju, like ketamine, rapidly increased the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus, whereas the BDNF mRNA expression remained unaltered. Yueju rapidly reduced the phosphorylation of eukaryotic elongation factor 2 (eEF2), leading to desuppression of BDNF synthesis. Unlike ketamine, both the BDNF expression and eEF2 phosphorylation were revered at 24 hours after Yueju administration. This study is the first to demonstrate the rapid antidepressant effects of an herb medicine, offering an opportunity to improve therapy of depression. |
format | Online Article Text |
id | pubmed-3654702 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-36547022013-05-24 Yueju Pill Rapidly Induces Antidepressant-Like Effects and Acutely Enhances BDNF Expression in Mouse Brain Xue, Wenda Zhou, Xin Yi, Nan Jiang, Lihua Tao, Weiwei Wu, Runjie Wang, Dan Jiang, Jingjing Ge, Xiaoyin Wang, Yuyue Wu, Haoxin Chen, Gang Evid Based Complement Alternat Med Research Article The traditional antidepressants have a major disadvantage in delayed onset of efficacy, and the emerging fast-acting antidepressant ketamine has adverse behavioral and neurotoxic effects. Yueju pill, an herb medicine formulated eight hundred years ago by Doctor Zhu Danxi, has been popularly prescribed in China for alleviation of depression-like symptoms. Although several clinical outcome studies reported the relative short onset of antidepressant effects of Yueju, this has not been scientifically investigated. We, therefore, examined the rapid antidepressant effect of Yueju in mice and tested the underlying molecular mechanisms. We found that acute administration of ethanol extract of Yueju rapidly attenuated depressive-like symptoms in learned helpless paradigm, and the antidepressant-like effects were sustained for at least 24 hours in tail suspension test in ICR mice. Additionally, Yueju, like ketamine, rapidly increased the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus, whereas the BDNF mRNA expression remained unaltered. Yueju rapidly reduced the phosphorylation of eukaryotic elongation factor 2 (eEF2), leading to desuppression of BDNF synthesis. Unlike ketamine, both the BDNF expression and eEF2 phosphorylation were revered at 24 hours after Yueju administration. This study is the first to demonstrate the rapid antidepressant effects of an herb medicine, offering an opportunity to improve therapy of depression. Hindawi Publishing Corporation 2013 2013-04-22 /pmc/articles/PMC3654702/ /pubmed/23710213 http://dx.doi.org/10.1155/2013/184367 Text en Copyright © 2013 Wenda Xue et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Xue, Wenda Zhou, Xin Yi, Nan Jiang, Lihua Tao, Weiwei Wu, Runjie Wang, Dan Jiang, Jingjing Ge, Xiaoyin Wang, Yuyue Wu, Haoxin Chen, Gang Yueju Pill Rapidly Induces Antidepressant-Like Effects and Acutely Enhances BDNF Expression in Mouse Brain |
title | Yueju Pill Rapidly Induces Antidepressant-Like Effects and Acutely Enhances BDNF Expression in Mouse Brain |
title_full | Yueju Pill Rapidly Induces Antidepressant-Like Effects and Acutely Enhances BDNF Expression in Mouse Brain |
title_fullStr | Yueju Pill Rapidly Induces Antidepressant-Like Effects and Acutely Enhances BDNF Expression in Mouse Brain |
title_full_unstemmed | Yueju Pill Rapidly Induces Antidepressant-Like Effects and Acutely Enhances BDNF Expression in Mouse Brain |
title_short | Yueju Pill Rapidly Induces Antidepressant-Like Effects and Acutely Enhances BDNF Expression in Mouse Brain |
title_sort | yueju pill rapidly induces antidepressant-like effects and acutely enhances bdnf expression in mouse brain |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654702/ https://www.ncbi.nlm.nih.gov/pubmed/23710213 http://dx.doi.org/10.1155/2013/184367 |
work_keys_str_mv | AT xuewenda yuejupillrapidlyinducesantidepressantlikeeffectsandacutelyenhancesbdnfexpressioninmousebrain AT zhouxin yuejupillrapidlyinducesantidepressantlikeeffectsandacutelyenhancesbdnfexpressioninmousebrain AT yinan yuejupillrapidlyinducesantidepressantlikeeffectsandacutelyenhancesbdnfexpressioninmousebrain AT jianglihua yuejupillrapidlyinducesantidepressantlikeeffectsandacutelyenhancesbdnfexpressioninmousebrain AT taoweiwei yuejupillrapidlyinducesantidepressantlikeeffectsandacutelyenhancesbdnfexpressioninmousebrain AT wurunjie yuejupillrapidlyinducesantidepressantlikeeffectsandacutelyenhancesbdnfexpressioninmousebrain AT wangdan yuejupillrapidlyinducesantidepressantlikeeffectsandacutelyenhancesbdnfexpressioninmousebrain AT jiangjingjing yuejupillrapidlyinducesantidepressantlikeeffectsandacutelyenhancesbdnfexpressioninmousebrain AT gexiaoyin yuejupillrapidlyinducesantidepressantlikeeffectsandacutelyenhancesbdnfexpressioninmousebrain AT wangyuyue yuejupillrapidlyinducesantidepressantlikeeffectsandacutelyenhancesbdnfexpressioninmousebrain AT wuhaoxin yuejupillrapidlyinducesantidepressantlikeeffectsandacutelyenhancesbdnfexpressioninmousebrain AT chengang yuejupillrapidlyinducesantidepressantlikeeffectsandacutelyenhancesbdnfexpressioninmousebrain |