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Yueju Pill Rapidly Induces Antidepressant-Like Effects and Acutely Enhances BDNF Expression in Mouse Brain

The traditional antidepressants have a major disadvantage in delayed onset of efficacy, and the emerging fast-acting antidepressant ketamine has adverse behavioral and neurotoxic effects. Yueju pill, an herb medicine formulated eight hundred years ago by Doctor Zhu Danxi, has been popularly prescrib...

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Autores principales: Xue, Wenda, Zhou, Xin, Yi, Nan, Jiang, Lihua, Tao, Weiwei, Wu, Runjie, Wang, Dan, Jiang, Jingjing, Ge, Xiaoyin, Wang, Yuyue, Wu, Haoxin, Chen, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654702/
https://www.ncbi.nlm.nih.gov/pubmed/23710213
http://dx.doi.org/10.1155/2013/184367
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author Xue, Wenda
Zhou, Xin
Yi, Nan
Jiang, Lihua
Tao, Weiwei
Wu, Runjie
Wang, Dan
Jiang, Jingjing
Ge, Xiaoyin
Wang, Yuyue
Wu, Haoxin
Chen, Gang
author_facet Xue, Wenda
Zhou, Xin
Yi, Nan
Jiang, Lihua
Tao, Weiwei
Wu, Runjie
Wang, Dan
Jiang, Jingjing
Ge, Xiaoyin
Wang, Yuyue
Wu, Haoxin
Chen, Gang
author_sort Xue, Wenda
collection PubMed
description The traditional antidepressants have a major disadvantage in delayed onset of efficacy, and the emerging fast-acting antidepressant ketamine has adverse behavioral and neurotoxic effects. Yueju pill, an herb medicine formulated eight hundred years ago by Doctor Zhu Danxi, has been popularly prescribed in China for alleviation of depression-like symptoms. Although several clinical outcome studies reported the relative short onset of antidepressant effects of Yueju, this has not been scientifically investigated. We, therefore, examined the rapid antidepressant effect of Yueju in mice and tested the underlying molecular mechanisms. We found that acute administration of ethanol extract of Yueju rapidly attenuated depressive-like symptoms in learned helpless paradigm, and the antidepressant-like effects were sustained for at least 24 hours in tail suspension test in ICR mice. Additionally, Yueju, like ketamine, rapidly increased the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus, whereas the BDNF mRNA expression remained unaltered. Yueju rapidly reduced the phosphorylation of eukaryotic elongation factor 2 (eEF2), leading to desuppression of BDNF synthesis. Unlike ketamine, both the BDNF expression and eEF2 phosphorylation were revered at 24 hours after Yueju administration. This study is the first to demonstrate the rapid antidepressant effects of an herb medicine, offering an opportunity to improve therapy of depression.
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spelling pubmed-36547022013-05-24 Yueju Pill Rapidly Induces Antidepressant-Like Effects and Acutely Enhances BDNF Expression in Mouse Brain Xue, Wenda Zhou, Xin Yi, Nan Jiang, Lihua Tao, Weiwei Wu, Runjie Wang, Dan Jiang, Jingjing Ge, Xiaoyin Wang, Yuyue Wu, Haoxin Chen, Gang Evid Based Complement Alternat Med Research Article The traditional antidepressants have a major disadvantage in delayed onset of efficacy, and the emerging fast-acting antidepressant ketamine has adverse behavioral and neurotoxic effects. Yueju pill, an herb medicine formulated eight hundred years ago by Doctor Zhu Danxi, has been popularly prescribed in China for alleviation of depression-like symptoms. Although several clinical outcome studies reported the relative short onset of antidepressant effects of Yueju, this has not been scientifically investigated. We, therefore, examined the rapid antidepressant effect of Yueju in mice and tested the underlying molecular mechanisms. We found that acute administration of ethanol extract of Yueju rapidly attenuated depressive-like symptoms in learned helpless paradigm, and the antidepressant-like effects were sustained for at least 24 hours in tail suspension test in ICR mice. Additionally, Yueju, like ketamine, rapidly increased the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus, whereas the BDNF mRNA expression remained unaltered. Yueju rapidly reduced the phosphorylation of eukaryotic elongation factor 2 (eEF2), leading to desuppression of BDNF synthesis. Unlike ketamine, both the BDNF expression and eEF2 phosphorylation were revered at 24 hours after Yueju administration. This study is the first to demonstrate the rapid antidepressant effects of an herb medicine, offering an opportunity to improve therapy of depression. Hindawi Publishing Corporation 2013 2013-04-22 /pmc/articles/PMC3654702/ /pubmed/23710213 http://dx.doi.org/10.1155/2013/184367 Text en Copyright © 2013 Wenda Xue et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Xue, Wenda
Zhou, Xin
Yi, Nan
Jiang, Lihua
Tao, Weiwei
Wu, Runjie
Wang, Dan
Jiang, Jingjing
Ge, Xiaoyin
Wang, Yuyue
Wu, Haoxin
Chen, Gang
Yueju Pill Rapidly Induces Antidepressant-Like Effects and Acutely Enhances BDNF Expression in Mouse Brain
title Yueju Pill Rapidly Induces Antidepressant-Like Effects and Acutely Enhances BDNF Expression in Mouse Brain
title_full Yueju Pill Rapidly Induces Antidepressant-Like Effects and Acutely Enhances BDNF Expression in Mouse Brain
title_fullStr Yueju Pill Rapidly Induces Antidepressant-Like Effects and Acutely Enhances BDNF Expression in Mouse Brain
title_full_unstemmed Yueju Pill Rapidly Induces Antidepressant-Like Effects and Acutely Enhances BDNF Expression in Mouse Brain
title_short Yueju Pill Rapidly Induces Antidepressant-Like Effects and Acutely Enhances BDNF Expression in Mouse Brain
title_sort yueju pill rapidly induces antidepressant-like effects and acutely enhances bdnf expression in mouse brain
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654702/
https://www.ncbi.nlm.nih.gov/pubmed/23710213
http://dx.doi.org/10.1155/2013/184367
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