Cargando…

Pheochromocytoma of the urinary bladder: a systematic review of the contemporary literature

BACKGROUND: Pheochromocytoma (paraganglioma) of the urinary bladder is a rare tumor. Herein we sought to review the contemporary literature on pheochromocytomas of the urinary bladder in order to further illustrate the presentation, treatment options and outcomes of patients diagnosed with these tum...

Descripción completa

Detalles Bibliográficos
Autores principales: Beilan, Jonathan A, Lawton, Adrienne, Hajdenberg, Julio, Rosser, Charles J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654956/
https://www.ncbi.nlm.nih.gov/pubmed/23627260
http://dx.doi.org/10.1186/1471-2490-13-22
_version_ 1782269800292024320
author Beilan, Jonathan A
Lawton, Adrienne
Hajdenberg, Julio
Rosser, Charles J
author_facet Beilan, Jonathan A
Lawton, Adrienne
Hajdenberg, Julio
Rosser, Charles J
author_sort Beilan, Jonathan A
collection PubMed
description BACKGROUND: Pheochromocytoma (paraganglioma) of the urinary bladder is a rare tumor. Herein we sought to review the contemporary literature on pheochromocytomas of the urinary bladder in order to further illustrate the presentation, treatment options and outcomes of patients diagnosed with these tumors. METHODS: A comprehensive review of the current literature was conducted according to the PRISMA guidelines by accessing the NCBI PubMed database and using the search terms “paraganglioma, pheochromocytoma, bladder.” This search resulted in the identification of 186 articles published between January 1980 and April 2012 of which 80 articles were ultimately included in our analysis. RESULTS: Pheochromocytomas usually occurred in young adult Caucasians (mean age, 43.3 years; range,11–84 years). According to the literature, the most common symptoms and signs of pheochromocytomas of the urinary bladder were hypertension, headache, and hematuria. Of the 77 cases that commented on catecholamine production, 65 patients had biochemically functional tumors. Approximately 20% of patients were treated by transurethral resection alone, 70% by partial cystectomy and 10% by radical cystectomy. The 75 patients with follow-up information had a mean follow-up of 35 months. At the time of last follow-up, 15 (14.2%) had disease recurrence, 10 (9.4%) had metastasis, and 65 (61.3%) were alive. CONCLUSIONS: Pheochromocytomas of the urinary bladder tend to be functional and occur mostly in young adult Caucasians. Patients with localized tumors have an extremely favorable prognosis and may be managed by less aggressive modalities, whereas patients with metastatic disease have a significant reduction in survival rates despite aggressive treatment.
format Online
Article
Text
id pubmed-3654956
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-36549562013-05-16 Pheochromocytoma of the urinary bladder: a systematic review of the contemporary literature Beilan, Jonathan A Lawton, Adrienne Hajdenberg, Julio Rosser, Charles J BMC Urol Research Article BACKGROUND: Pheochromocytoma (paraganglioma) of the urinary bladder is a rare tumor. Herein we sought to review the contemporary literature on pheochromocytomas of the urinary bladder in order to further illustrate the presentation, treatment options and outcomes of patients diagnosed with these tumors. METHODS: A comprehensive review of the current literature was conducted according to the PRISMA guidelines by accessing the NCBI PubMed database and using the search terms “paraganglioma, pheochromocytoma, bladder.” This search resulted in the identification of 186 articles published between January 1980 and April 2012 of which 80 articles were ultimately included in our analysis. RESULTS: Pheochromocytomas usually occurred in young adult Caucasians (mean age, 43.3 years; range,11–84 years). According to the literature, the most common symptoms and signs of pheochromocytomas of the urinary bladder were hypertension, headache, and hematuria. Of the 77 cases that commented on catecholamine production, 65 patients had biochemically functional tumors. Approximately 20% of patients were treated by transurethral resection alone, 70% by partial cystectomy and 10% by radical cystectomy. The 75 patients with follow-up information had a mean follow-up of 35 months. At the time of last follow-up, 15 (14.2%) had disease recurrence, 10 (9.4%) had metastasis, and 65 (61.3%) were alive. CONCLUSIONS: Pheochromocytomas of the urinary bladder tend to be functional and occur mostly in young adult Caucasians. Patients with localized tumors have an extremely favorable prognosis and may be managed by less aggressive modalities, whereas patients with metastatic disease have a significant reduction in survival rates despite aggressive treatment. BioMed Central 2013-04-29 /pmc/articles/PMC3654956/ /pubmed/23627260 http://dx.doi.org/10.1186/1471-2490-13-22 Text en Copyright © 2013 Beilan et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Beilan, Jonathan A
Lawton, Adrienne
Hajdenberg, Julio
Rosser, Charles J
Pheochromocytoma of the urinary bladder: a systematic review of the contemporary literature
title Pheochromocytoma of the urinary bladder: a systematic review of the contemporary literature
title_full Pheochromocytoma of the urinary bladder: a systematic review of the contemporary literature
title_fullStr Pheochromocytoma of the urinary bladder: a systematic review of the contemporary literature
title_full_unstemmed Pheochromocytoma of the urinary bladder: a systematic review of the contemporary literature
title_short Pheochromocytoma of the urinary bladder: a systematic review of the contemporary literature
title_sort pheochromocytoma of the urinary bladder: a systematic review of the contemporary literature
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654956/
https://www.ncbi.nlm.nih.gov/pubmed/23627260
http://dx.doi.org/10.1186/1471-2490-13-22
work_keys_str_mv AT beilanjonathana pheochromocytomaoftheurinarybladderasystematicreviewofthecontemporaryliterature
AT lawtonadrienne pheochromocytomaoftheurinarybladderasystematicreviewofthecontemporaryliterature
AT hajdenbergjulio pheochromocytomaoftheurinarybladderasystematicreviewofthecontemporaryliterature
AT rossercharlesj pheochromocytomaoftheurinarybladderasystematicreviewofthecontemporaryliterature