Proteolysis of Xenopus Cip-type CDK inhibitor, p16(Xic2), is regulated by PCNA binding and CDK2 phosphorylation

BACKGROUND: Cell division is positively regulated by cyclin-dependent kinases (CDKs) partnered with cyclins and negatively regulated by CDK inhibitors. In the frog, Xenopus laevis, three types of CDK inhibitors have been described: p27(Xic1) (Xic1) which shares sequence homology with both p21(Cip1)...

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Detalles Bibliográficos
Autores principales: Zhu, Xi-Ning, Kim, Dong Hyun, Lin, Horng-Ru, Budhavarapu, Varija N, Rosenbaum, Herbert B, Mueller, Paul R, Yew, P Renee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655096/
https://www.ncbi.nlm.nih.gov/pubmed/23607668
http://dx.doi.org/10.1186/1747-1028-8-5

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