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Treatment of obstructive sleep apnea using a custom-made titratable duobloc oral appliance: a prospective clinical study

PURPOSE: This prospective clinical study investigates the efficacy of a specific custom-made titratable mandibular advancement device (MAD) for the treatment of obstructive sleep apnea (OSA). This MAD has attachments in the frontal teeth area that allow for progressive titration of the mandible. MET...

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Autores principales: Dieltjens, M., Vanderveken, O. M., Hamans, E., Verbraecken, J. A., Wouters, K., Willemen, M., De Backer, W. A., Van de Heyning, P. H., Braem, M. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655219/
https://www.ncbi.nlm.nih.gov/pubmed/22581485
http://dx.doi.org/10.1007/s11325-012-0721-3
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author Dieltjens, M.
Vanderveken, O. M.
Hamans, E.
Verbraecken, J. A.
Wouters, K.
Willemen, M.
De Backer, W. A.
Van de Heyning, P. H.
Braem, M. J.
author_facet Dieltjens, M.
Vanderveken, O. M.
Hamans, E.
Verbraecken, J. A.
Wouters, K.
Willemen, M.
De Backer, W. A.
Van de Heyning, P. H.
Braem, M. J.
author_sort Dieltjens, M.
collection PubMed
description PURPOSE: This prospective clinical study investigates the efficacy of a specific custom-made titratable mandibular advancement device (MAD) for the treatment of obstructive sleep apnea (OSA). This MAD has attachments in the frontal teeth area that allow for progressive titration of the mandible. METHODS: Sixty-one adult OSA patients were included (age, 46.7 ± 9.0 years; male/female ratio, 45/16; apnea–hypopnea index (AHI), 23.2 ± 15.4 events/h sleep; body mass index, 27.9 ± 4.1 kg/m²). After an adaptation period, titration started based on a protocol of symptomatic benefit or upon reaching the physiological limits of protrusion. As a primary outcome, treatment response was defined as an objective reduction in AHI following MAD treatment of ≥50 % compared to baseline, and treatment success as a reduction in AHI with MAD to less than 5 and 10 events/h sleep. Compliance failure was defined as an inability to continue treatment. RESULTS: A statistically significant decrease was observed in AHI, from 23.4 ± 15.7 at baseline to 8.9 ± 8.6 events/h with MAD (p < 0.01). Treatment response was achieved in 42 out of 61 patients (68.8 %), whereas 42.6 % met criteria of AHI < 5 and 63.9 % achieved an AHI < 10 events/h sleep, respectively. Four patients (6.6 %) were considered as “compliance failures.” CONCLUSIONS: The present study has evaluated the efficacy of a specific custom-made titratable MAD in terms of sleep apnea reduction.
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spelling pubmed-36552192013-05-16 Treatment of obstructive sleep apnea using a custom-made titratable duobloc oral appliance: a prospective clinical study Dieltjens, M. Vanderveken, O. M. Hamans, E. Verbraecken, J. A. Wouters, K. Willemen, M. De Backer, W. A. Van de Heyning, P. H. Braem, M. J. Sleep Breath Original Article PURPOSE: This prospective clinical study investigates the efficacy of a specific custom-made titratable mandibular advancement device (MAD) for the treatment of obstructive sleep apnea (OSA). This MAD has attachments in the frontal teeth area that allow for progressive titration of the mandible. METHODS: Sixty-one adult OSA patients were included (age, 46.7 ± 9.0 years; male/female ratio, 45/16; apnea–hypopnea index (AHI), 23.2 ± 15.4 events/h sleep; body mass index, 27.9 ± 4.1 kg/m²). After an adaptation period, titration started based on a protocol of symptomatic benefit or upon reaching the physiological limits of protrusion. As a primary outcome, treatment response was defined as an objective reduction in AHI following MAD treatment of ≥50 % compared to baseline, and treatment success as a reduction in AHI with MAD to less than 5 and 10 events/h sleep. Compliance failure was defined as an inability to continue treatment. RESULTS: A statistically significant decrease was observed in AHI, from 23.4 ± 15.7 at baseline to 8.9 ± 8.6 events/h with MAD (p < 0.01). Treatment response was achieved in 42 out of 61 patients (68.8 %), whereas 42.6 % met criteria of AHI < 5 and 63.9 % achieved an AHI < 10 events/h sleep, respectively. Four patients (6.6 %) were considered as “compliance failures.” CONCLUSIONS: The present study has evaluated the efficacy of a specific custom-made titratable MAD in terms of sleep apnea reduction. Springer-Verlag 2012-05-13 2013 /pmc/articles/PMC3655219/ /pubmed/22581485 http://dx.doi.org/10.1007/s11325-012-0721-3 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Original Article
Dieltjens, M.
Vanderveken, O. M.
Hamans, E.
Verbraecken, J. A.
Wouters, K.
Willemen, M.
De Backer, W. A.
Van de Heyning, P. H.
Braem, M. J.
Treatment of obstructive sleep apnea using a custom-made titratable duobloc oral appliance: a prospective clinical study
title Treatment of obstructive sleep apnea using a custom-made titratable duobloc oral appliance: a prospective clinical study
title_full Treatment of obstructive sleep apnea using a custom-made titratable duobloc oral appliance: a prospective clinical study
title_fullStr Treatment of obstructive sleep apnea using a custom-made titratable duobloc oral appliance: a prospective clinical study
title_full_unstemmed Treatment of obstructive sleep apnea using a custom-made titratable duobloc oral appliance: a prospective clinical study
title_short Treatment of obstructive sleep apnea using a custom-made titratable duobloc oral appliance: a prospective clinical study
title_sort treatment of obstructive sleep apnea using a custom-made titratable duobloc oral appliance: a prospective clinical study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655219/
https://www.ncbi.nlm.nih.gov/pubmed/22581485
http://dx.doi.org/10.1007/s11325-012-0721-3
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