A Large-Scale Conformational Change Couples Membrane Recruitment to Cargo Binding in the AP2 Clathrin Adaptor Complex

The AP2 adaptor complex (α, β2, σ2, and μ2 subunits) crosslinks the endocytic clathrin scaffold to PtdIns4,5P(2)-containing membranes and transmembrane protein cargo. In the “locked” cytosolic form, AP2's binding sites for the two endocytic motifs, YxxΦ on the C-terminal domain of μ2 (C-μ2) and...

Descripción completa

Detalles Bibliográficos
Autores principales: Jackson, Lauren P., Kelly, Bernard T., McCoy, Airlie J., Gaffry, Thomas, James, Leo C., Collins, Brett M., Höning, Stefan, Evans, Philip R., Owen, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655264/
https://www.ncbi.nlm.nih.gov/pubmed/20603002
http://dx.doi.org/10.1016/j.cell.2010.05.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655264/
https://www.ncbi.nlm.nih.gov/pubmed/20603002
http://dx.doi.org/10.1016/j.cell.2010.05.006

Ejemplares similares