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Diffuse Thyroid Uptake Incidentally Found on (18)F-Fluorodeoxyglucose Positron Emission Tomography in Subjects without Cancer History
OBJECTIVE: We investigated the clinical significance of incidental diffuse thyroid uptake (DTU) on (18)F-FDG PET in subjects without a history of cancer. MATERIALS AND METHODS: This study included 2062 studies from adults who underwent (18)F-FDG PET as a cancer screening program. Subjects were divid...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Korean Society of Radiology
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655308/ https://www.ncbi.nlm.nih.gov/pubmed/23690721 http://dx.doi.org/10.3348/kjr.2013.14.3.501 |
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author | Lee, Ji Young Choi, Joon Young Choi, Yoon-Ho Hyun, Seung Hyup Moon, Seung Hwan Jang, Su Jin Choe, Yearn Seong Lee, Kyung-Han Kim, Byung-Tae |
author_facet | Lee, Ji Young Choi, Joon Young Choi, Yoon-Ho Hyun, Seung Hyup Moon, Seung Hwan Jang, Su Jin Choe, Yearn Seong Lee, Kyung-Han Kim, Byung-Tae |
author_sort | Lee, Ji Young |
collection | PubMed |
description | OBJECTIVE: We investigated the clinical significance of incidental diffuse thyroid uptake (DTU) on (18)F-FDG PET in subjects without a history of cancer. MATERIALS AND METHODS: This study included 2062 studies from adults who underwent (18)F-FDG PET as a cancer screening program. Subjects were divided into the following two groups: with (group I) or without (group II) DTU. The presence of DTU and the thyroid visual grading score were compared with thyroid function tests, serum anti-microsomal antibody (AMA) levels, and the presence of diffuse parenchymal change (DPC) on ultrasonography (USG). RESULTS: DTU was found in 6.6% of the scans (137/2062). Serum thyroid stimulating hormone (TSH) and AMA levels were significantly higher in group I than in group II. Increased AMA level (55.1%) and DPC (48.7%) were more frequently found in group I (p < 0.001). The proportion of subjects with any abnormal results in serum free thyroxine, triiodothyronine, TSH, or AMA levels or DPC on USG was significantly higher in group I than in group II (71.5% vs. 10.6%, p < 0.001), and was significantly and gradually increased according to the visual grading score group (0 vs. 1-2 vs. 3-4 = 10.6% vs. 58.5% vs. 90.9%, p < 0.001). TSH and is AMA levels were significantly increased according to the visual grading score. CONCLUSION: The presence or degree of incidental DTU on (18)F-FDG PET is closely correlated with increased serum AMA and TSH levels, and the presence of DPC on USG. Therefore, the most plausible pathological cause of DTU may be cell damage by an autoimmune mechanism. |
format | Online Article Text |
id | pubmed-3655308 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | The Korean Society of Radiology |
record_format | MEDLINE/PubMed |
spelling | pubmed-36553082013-05-20 Diffuse Thyroid Uptake Incidentally Found on (18)F-Fluorodeoxyglucose Positron Emission Tomography in Subjects without Cancer History Lee, Ji Young Choi, Joon Young Choi, Yoon-Ho Hyun, Seung Hyup Moon, Seung Hwan Jang, Su Jin Choe, Yearn Seong Lee, Kyung-Han Kim, Byung-Tae Korean J Radiol Nuclear Medicine OBJECTIVE: We investigated the clinical significance of incidental diffuse thyroid uptake (DTU) on (18)F-FDG PET in subjects without a history of cancer. MATERIALS AND METHODS: This study included 2062 studies from adults who underwent (18)F-FDG PET as a cancer screening program. Subjects were divided into the following two groups: with (group I) or without (group II) DTU. The presence of DTU and the thyroid visual grading score were compared with thyroid function tests, serum anti-microsomal antibody (AMA) levels, and the presence of diffuse parenchymal change (DPC) on ultrasonography (USG). RESULTS: DTU was found in 6.6% of the scans (137/2062). Serum thyroid stimulating hormone (TSH) and AMA levels were significantly higher in group I than in group II. Increased AMA level (55.1%) and DPC (48.7%) were more frequently found in group I (p < 0.001). The proportion of subjects with any abnormal results in serum free thyroxine, triiodothyronine, TSH, or AMA levels or DPC on USG was significantly higher in group I than in group II (71.5% vs. 10.6%, p < 0.001), and was significantly and gradually increased according to the visual grading score group (0 vs. 1-2 vs. 3-4 = 10.6% vs. 58.5% vs. 90.9%, p < 0.001). TSH and is AMA levels were significantly increased according to the visual grading score. CONCLUSION: The presence or degree of incidental DTU on (18)F-FDG PET is closely correlated with increased serum AMA and TSH levels, and the presence of DPC on USG. Therefore, the most plausible pathological cause of DTU may be cell damage by an autoimmune mechanism. The Korean Society of Radiology 2013 2013-05-02 /pmc/articles/PMC3655308/ /pubmed/23690721 http://dx.doi.org/10.3348/kjr.2013.14.3.501 Text en Copyright © 2013 The Korean Society of Radiology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Nuclear Medicine Lee, Ji Young Choi, Joon Young Choi, Yoon-Ho Hyun, Seung Hyup Moon, Seung Hwan Jang, Su Jin Choe, Yearn Seong Lee, Kyung-Han Kim, Byung-Tae Diffuse Thyroid Uptake Incidentally Found on (18)F-Fluorodeoxyglucose Positron Emission Tomography in Subjects without Cancer History |
title | Diffuse Thyroid Uptake Incidentally Found on (18)F-Fluorodeoxyglucose Positron Emission Tomography in Subjects without Cancer History |
title_full | Diffuse Thyroid Uptake Incidentally Found on (18)F-Fluorodeoxyglucose Positron Emission Tomography in Subjects without Cancer History |
title_fullStr | Diffuse Thyroid Uptake Incidentally Found on (18)F-Fluorodeoxyglucose Positron Emission Tomography in Subjects without Cancer History |
title_full_unstemmed | Diffuse Thyroid Uptake Incidentally Found on (18)F-Fluorodeoxyglucose Positron Emission Tomography in Subjects without Cancer History |
title_short | Diffuse Thyroid Uptake Incidentally Found on (18)F-Fluorodeoxyglucose Positron Emission Tomography in Subjects without Cancer History |
title_sort | diffuse thyroid uptake incidentally found on (18)f-fluorodeoxyglucose positron emission tomography in subjects without cancer history |
topic | Nuclear Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655308/ https://www.ncbi.nlm.nih.gov/pubmed/23690721 http://dx.doi.org/10.3348/kjr.2013.14.3.501 |
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