Truncated p110 ERBB2 induces mammary epithelial cell migration, invasion and orthotopic xenograft formation, and is associated with loss of phosphorylated STAT5

Truncated-ERBB2 isoforms (t-ERBB2s), resulting from receptor proteolysis or alternative translation of the ERBB2 mRNA, exist in a subset of human breast tumors. t-ERBB2s lack the receptor extracellular domain targeted by therapeutic anti-ERBB2 antibodies and antibody–drug conjugates, including trast...

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Detalles Bibliográficos
Autores principales: Ward, T M, Iorns, E, Liu, X, Hoe, N, Kim, P, Singh, S, Dean, S, Jegg, A-M, Gallas, M, Rodriguez, C, Lippman, M, Landgraf, R, Pegram, M D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655379/
https://www.ncbi.nlm.nih.gov/pubmed/22751112
http://dx.doi.org/10.1038/onc.2012.256

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