Amyloid β inhibits retinoic acid synthesis exacerbating Alzheimer disease pathology which can be attenuated by an retinoic acid receptor α agonist

The retinoic acid receptor (RAR) α system plays a key role in the adult brain, participating in the homeostatic control of synaptic plasticity, essential for memory function. Here we show that RARα signalling is down-regulated by amyloid beta (Aβ), which inhibits the synthesis of the endogenous liga...

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Detalles Bibliográficos
Autores principales: Goncalves, Maria B, Clarke, Earl, Hobbs, Carl, Malmqvist, Tony, Deacon, Robert, Jack, Julian, Corcoran, Jonathan P T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Disorders of the Nervous System
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655538/
https://www.ncbi.nlm.nih.gov/pubmed/23379615
http://dx.doi.org/10.1111/ejn.12142

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655538/
https://www.ncbi.nlm.nih.gov/pubmed/23379615
http://dx.doi.org/10.1111/ejn.12142

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