Application of IgG-Derived Natural Treg Epitopes (IgG Tregitopes) to Antigen-Specific Tolerance Induction in a Murine Model of Type 1 Diabetes

HLA class II-restricted regulatory T cell (Treg) epitopes in IgG (also called “Tregitopes”) have been reported to suppress immune responses to coadministered antigens by stimulating the expansion of natural Tregs (nTregs). Here we evaluate their impact on human immune responses to islet cell antigen...

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Detalles Bibliográficos
Autores principales: Cousens, Leslie P., Su, Yan, McClaine, Elizabeth, Li, Xin, Terry, Frances, Smith, Robert, Lee, Jinhee, Martin, William, Scott, David W., De Groot, Anne S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655598/
https://www.ncbi.nlm.nih.gov/pubmed/23710469
http://dx.doi.org/10.1155/2013/621693

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