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Greater Skeletal Gains in Ovary Intact Rats at Maturity Are Achieved by Supplementing a Standardized Extract of Butea monosperma Stem Bark that Confers Better Bone Conserving Effect following Ovariectomy and Concurrent Treatment Withdrawal

With a longitudinally designed study, we tested whether an acetone soluble fraction (ASF) from the stem bark of Butea monosperma resulted in maximizing bone gain in rats during growth and maturation and thus protected against osteopenia following ovariectomy (OVx) with concomitant treatment withdraw...

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Autores principales: Srivastava, Kamini, Khan, Kainat, Tyagi, Abdul M., Khan, Mohd. P., Yadav, Dinesh K., Trivedi, Ritu, Maurya, Rakesh, Singh, Divya, Chattopadhyay, Naibedya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655608/
https://www.ncbi.nlm.nih.gov/pubmed/23710224
http://dx.doi.org/10.1155/2013/519387
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author Srivastava, Kamini
Khan, Kainat
Tyagi, Abdul M.
Khan, Mohd. P.
Yadav, Dinesh K.
Trivedi, Ritu
Maurya, Rakesh
Singh, Divya
Chattopadhyay, Naibedya
author_facet Srivastava, Kamini
Khan, Kainat
Tyagi, Abdul M.
Khan, Mohd. P.
Yadav, Dinesh K.
Trivedi, Ritu
Maurya, Rakesh
Singh, Divya
Chattopadhyay, Naibedya
author_sort Srivastava, Kamini
collection PubMed
description With a longitudinally designed study, we tested whether an acetone soluble fraction (ASF) from the stem bark of Butea monosperma resulted in maximizing bone gain in rats during growth and maturation and thus protected against osteopenia following ovariectomy (OVx) with concomitant treatment withdrawal. Female rats at weaning were given ASF (100 mg/kg/d) or vehicle for 12 weeks, and baseline skeletal parameters (micro-CT) and total plasma antioxidant status (TAS) were measured. At this stage, one group was OVx and the other group was sham operated. Vehicle group (untreated) after OVx was given E2 or continued with vehicle (OVx control). ASF group after OVx was given vehicle (ASF withdrawn, ASFW). After another 12 weeks, all groups were killed and various skeletal parameters were determined. ASF resulted in substantially better skeletal parameters and higher plasma TAS over control at maturity. Rats treated with ASF before OVx had reduced rates of bone loss compared to OVx control. Twelve weeks after OVx, the ASFW group exhibited better trabecular microarchitectural preservation, bone turnover profiles, increased cortical deposition, and biomechanical strength over the OVx control, and the effects were comparable to OVx + E2 group. ASF supplementation during skeletal growth could maximize bone accrual and could confer increased resistance to post-OVx osteopenia despite treatment withdrawal.
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spelling pubmed-36556082013-05-24 Greater Skeletal Gains in Ovary Intact Rats at Maturity Are Achieved by Supplementing a Standardized Extract of Butea monosperma Stem Bark that Confers Better Bone Conserving Effect following Ovariectomy and Concurrent Treatment Withdrawal Srivastava, Kamini Khan, Kainat Tyagi, Abdul M. Khan, Mohd. P. Yadav, Dinesh K. Trivedi, Ritu Maurya, Rakesh Singh, Divya Chattopadhyay, Naibedya Evid Based Complement Alternat Med Research Article With a longitudinally designed study, we tested whether an acetone soluble fraction (ASF) from the stem bark of Butea monosperma resulted in maximizing bone gain in rats during growth and maturation and thus protected against osteopenia following ovariectomy (OVx) with concomitant treatment withdrawal. Female rats at weaning were given ASF (100 mg/kg/d) or vehicle for 12 weeks, and baseline skeletal parameters (micro-CT) and total plasma antioxidant status (TAS) were measured. At this stage, one group was OVx and the other group was sham operated. Vehicle group (untreated) after OVx was given E2 or continued with vehicle (OVx control). ASF group after OVx was given vehicle (ASF withdrawn, ASFW). After another 12 weeks, all groups were killed and various skeletal parameters were determined. ASF resulted in substantially better skeletal parameters and higher plasma TAS over control at maturity. Rats treated with ASF before OVx had reduced rates of bone loss compared to OVx control. Twelve weeks after OVx, the ASFW group exhibited better trabecular microarchitectural preservation, bone turnover profiles, increased cortical deposition, and biomechanical strength over the OVx control, and the effects were comparable to OVx + E2 group. ASF supplementation during skeletal growth could maximize bone accrual and could confer increased resistance to post-OVx osteopenia despite treatment withdrawal. Hindawi Publishing Corporation 2013 2013-04-27 /pmc/articles/PMC3655608/ /pubmed/23710224 http://dx.doi.org/10.1155/2013/519387 Text en Copyright © 2013 Kamini Srivastava et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Srivastava, Kamini
Khan, Kainat
Tyagi, Abdul M.
Khan, Mohd. P.
Yadav, Dinesh K.
Trivedi, Ritu
Maurya, Rakesh
Singh, Divya
Chattopadhyay, Naibedya
Greater Skeletal Gains in Ovary Intact Rats at Maturity Are Achieved by Supplementing a Standardized Extract of Butea monosperma Stem Bark that Confers Better Bone Conserving Effect following Ovariectomy and Concurrent Treatment Withdrawal
title Greater Skeletal Gains in Ovary Intact Rats at Maturity Are Achieved by Supplementing a Standardized Extract of Butea monosperma Stem Bark that Confers Better Bone Conserving Effect following Ovariectomy and Concurrent Treatment Withdrawal
title_full Greater Skeletal Gains in Ovary Intact Rats at Maturity Are Achieved by Supplementing a Standardized Extract of Butea monosperma Stem Bark that Confers Better Bone Conserving Effect following Ovariectomy and Concurrent Treatment Withdrawal
title_fullStr Greater Skeletal Gains in Ovary Intact Rats at Maturity Are Achieved by Supplementing a Standardized Extract of Butea monosperma Stem Bark that Confers Better Bone Conserving Effect following Ovariectomy and Concurrent Treatment Withdrawal
title_full_unstemmed Greater Skeletal Gains in Ovary Intact Rats at Maturity Are Achieved by Supplementing a Standardized Extract of Butea monosperma Stem Bark that Confers Better Bone Conserving Effect following Ovariectomy and Concurrent Treatment Withdrawal
title_short Greater Skeletal Gains in Ovary Intact Rats at Maturity Are Achieved by Supplementing a Standardized Extract of Butea monosperma Stem Bark that Confers Better Bone Conserving Effect following Ovariectomy and Concurrent Treatment Withdrawal
title_sort greater skeletal gains in ovary intact rats at maturity are achieved by supplementing a standardized extract of butea monosperma stem bark that confers better bone conserving effect following ovariectomy and concurrent treatment withdrawal
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655608/
https://www.ncbi.nlm.nih.gov/pubmed/23710224
http://dx.doi.org/10.1155/2013/519387
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