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Serum Procalcitonine Levels as an Early Diagnostic Indicator of Sepsis

INTRODUCTION: Prompt and accurate diagnosis of sepsis is of high importance for clinicians. Procalcitonine (PCT) and C-reactive protein (CRP) have been proposed as markers for this purpose. Our aim was to evaluate the levels of PCT and CRP in early sepsis and its correlation with severity of sepsis....

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Autores principales: Beqja-Lika, Anila, Bulo-Kasneci, Anyla, Refatllari, Etleva, Heta-Alliu, Nevila, Rucaj-Barbullushi, Alma, Mone, Iris, Mitre, Anila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AVICENA, d.o.o., Sarajevo 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655734/
https://www.ncbi.nlm.nih.gov/pubmed/23687457
http://dx.doi.org/10.5455/msm.2013.25.23-25
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author Beqja-Lika, Anila
Bulo-Kasneci, Anyla
Refatllari, Etleva
Heta-Alliu, Nevila
Rucaj-Barbullushi, Alma
Mone, Iris
Mitre, Anila
author_facet Beqja-Lika, Anila
Bulo-Kasneci, Anyla
Refatllari, Etleva
Heta-Alliu, Nevila
Rucaj-Barbullushi, Alma
Mone, Iris
Mitre, Anila
author_sort Beqja-Lika, Anila
collection PubMed
description INTRODUCTION: Prompt and accurate diagnosis of sepsis is of high importance for clinicians. Procalcitonine (PCT) and C-reactive protein (CRP) have been proposed as markers for this purpose. Our aim was to evaluate the levels of PCT and CRP in early sepsis and its correlation with severity of sepsis. METHODS: Levels of PCT and CRP were taken from 60 patients with sepsis criteria and 39 patients with SIRS symptoms from the University Hospital Center “Mother Teresa” in Tirana, Albania during 2010-2012. Sensitivity, specificity and predictive values for PCT and CRP were calculated. RESULTS: PCT and CRP levels increased in parallel with the severity of the clinical conditions of the patients. The mean PCT level in patients with sepsis was 11.28 ng/ml versus 0.272 ng/ml in patients with SIRS symptoms, with a sensitivity of 97.4% and a specificity of 96.6% for PCT >0.5ng/ml. The mean CRP level in septic patients was 146.58 mg/l vs. 34.4 mg/l in patients with SIRS, with a sensitivity of 98.6% for sepsis and a specificity of 75 % for CRP >11mg/l. CONCLUSION: PCT and CRP values are useful markers to determine early diagnosis and severity of an infection. In the present study, PCT was found to be a more accurate diagnostic parameter for differentiating SIRS from sepsis and may be helpful in the follow-up of critically ill patients.
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spelling pubmed-36557342013-05-17 Serum Procalcitonine Levels as an Early Diagnostic Indicator of Sepsis Beqja-Lika, Anila Bulo-Kasneci, Anyla Refatllari, Etleva Heta-Alliu, Nevila Rucaj-Barbullushi, Alma Mone, Iris Mitre, Anila Mater Sociomed Original Paper INTRODUCTION: Prompt and accurate diagnosis of sepsis is of high importance for clinicians. Procalcitonine (PCT) and C-reactive protein (CRP) have been proposed as markers for this purpose. Our aim was to evaluate the levels of PCT and CRP in early sepsis and its correlation with severity of sepsis. METHODS: Levels of PCT and CRP were taken from 60 patients with sepsis criteria and 39 patients with SIRS symptoms from the University Hospital Center “Mother Teresa” in Tirana, Albania during 2010-2012. Sensitivity, specificity and predictive values for PCT and CRP were calculated. RESULTS: PCT and CRP levels increased in parallel with the severity of the clinical conditions of the patients. The mean PCT level in patients with sepsis was 11.28 ng/ml versus 0.272 ng/ml in patients with SIRS symptoms, with a sensitivity of 97.4% and a specificity of 96.6% for PCT >0.5ng/ml. The mean CRP level in septic patients was 146.58 mg/l vs. 34.4 mg/l in patients with SIRS, with a sensitivity of 98.6% for sepsis and a specificity of 75 % for CRP >11mg/l. CONCLUSION: PCT and CRP values are useful markers to determine early diagnosis and severity of an infection. In the present study, PCT was found to be a more accurate diagnostic parameter for differentiating SIRS from sepsis and may be helpful in the follow-up of critically ill patients. AVICENA, d.o.o., Sarajevo 2013 /pmc/articles/PMC3655734/ /pubmed/23687457 http://dx.doi.org/10.5455/msm.2013.25.23-25 Text en © 2013 AVICENA http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Paper
Beqja-Lika, Anila
Bulo-Kasneci, Anyla
Refatllari, Etleva
Heta-Alliu, Nevila
Rucaj-Barbullushi, Alma
Mone, Iris
Mitre, Anila
Serum Procalcitonine Levels as an Early Diagnostic Indicator of Sepsis
title Serum Procalcitonine Levels as an Early Diagnostic Indicator of Sepsis
title_full Serum Procalcitonine Levels as an Early Diagnostic Indicator of Sepsis
title_fullStr Serum Procalcitonine Levels as an Early Diagnostic Indicator of Sepsis
title_full_unstemmed Serum Procalcitonine Levels as an Early Diagnostic Indicator of Sepsis
title_short Serum Procalcitonine Levels as an Early Diagnostic Indicator of Sepsis
title_sort serum procalcitonine levels as an early diagnostic indicator of sepsis
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655734/
https://www.ncbi.nlm.nih.gov/pubmed/23687457
http://dx.doi.org/10.5455/msm.2013.25.23-25
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