Molecular diversity and population structure at the Cytochrome P450 3A5 gene in Africa

BACKGROUND: Cytochrome P450 3A5 (CYP3A5) is an enzyme involved in the metabolism of many therapeutic drugs. CYP3A5 expression levels vary between individuals and populations, and this contributes to adverse clinical outcomes. Variable expression is largely attributed to four alleles, CYP3A5*1 (expre...

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Detalles Bibliográficos
Autores principales: Bains, Ripudaman K, Kovacevic, Mirna, Plaster, Christopher A, Tarekegn, Ayele, Bekele, Endashaw, Bradman, Neil N, Thomas, Mark G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655848/
https://www.ncbi.nlm.nih.gov/pubmed/23641907
http://dx.doi.org/10.1186/1471-2156-14-34

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