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How do autoimmune diseases cluster in families? A systematic review and meta-analysis
BACKGROUND: A primary characteristic of complex genetic diseases is that affected individuals tend to cluster in families (that is, familial aggregation). Aggregation of the same autoimmune condition, also referred to as familial autoimmune disease, has been extensively evaluated. However, aggregati...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655934/ https://www.ncbi.nlm.nih.gov/pubmed/23497011 http://dx.doi.org/10.1186/1741-7015-11-73 |
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author | Cárdenas-Roldán, Jorge Rojas-Villarraga, Adriana Anaya, Juan-Manuel |
author_facet | Cárdenas-Roldán, Jorge Rojas-Villarraga, Adriana Anaya, Juan-Manuel |
author_sort | Cárdenas-Roldán, Jorge |
collection | PubMed |
description | BACKGROUND: A primary characteristic of complex genetic diseases is that affected individuals tend to cluster in families (that is, familial aggregation). Aggregation of the same autoimmune condition, also referred to as familial autoimmune disease, has been extensively evaluated. However, aggregation of diverse autoimmune diseases, also known as familial autoimmunity, has been overlooked. Therefore, a systematic review and meta-analysis were performed aimed at gathering evidence about this topic. METHODS: Familial autoimmunity was investigated in five major autoimmune diseases, namely, rheumatoid arthritis, systemic lupus erythematosus, autoimmune thyroid disease, multiple sclerosis and type 1 diabetes mellitus. Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines were followed. Articles were searched in Pubmed and Embase databases. RESULTS: Out of a total of 61 articles, 44 were selected for final analysis. Familial autoimmunity was found in all the autoimmune diseases investigated. Aggregation of autoimmune thyroid disease, followed by systemic lupus erythematosus and rheumatoid arthritis, was the most encountered. CONCLUSIONS: Familial autoimmunity is a frequently seen condition. Further study of familial autoimmunity will help to decipher the common mechanisms of autoimmunity. |
format | Online Article Text |
id | pubmed-3655934 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-36559342013-05-17 How do autoimmune diseases cluster in families? A systematic review and meta-analysis Cárdenas-Roldán, Jorge Rojas-Villarraga, Adriana Anaya, Juan-Manuel BMC Med Research Article BACKGROUND: A primary characteristic of complex genetic diseases is that affected individuals tend to cluster in families (that is, familial aggregation). Aggregation of the same autoimmune condition, also referred to as familial autoimmune disease, has been extensively evaluated. However, aggregation of diverse autoimmune diseases, also known as familial autoimmunity, has been overlooked. Therefore, a systematic review and meta-analysis were performed aimed at gathering evidence about this topic. METHODS: Familial autoimmunity was investigated in five major autoimmune diseases, namely, rheumatoid arthritis, systemic lupus erythematosus, autoimmune thyroid disease, multiple sclerosis and type 1 diabetes mellitus. Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines were followed. Articles were searched in Pubmed and Embase databases. RESULTS: Out of a total of 61 articles, 44 were selected for final analysis. Familial autoimmunity was found in all the autoimmune diseases investigated. Aggregation of autoimmune thyroid disease, followed by systemic lupus erythematosus and rheumatoid arthritis, was the most encountered. CONCLUSIONS: Familial autoimmunity is a frequently seen condition. Further study of familial autoimmunity will help to decipher the common mechanisms of autoimmunity. BioMed Central 2013-03-18 /pmc/articles/PMC3655934/ /pubmed/23497011 http://dx.doi.org/10.1186/1741-7015-11-73 Text en Copyright © 2013 Cárdenas-Roldán et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Cárdenas-Roldán, Jorge Rojas-Villarraga, Adriana Anaya, Juan-Manuel How do autoimmune diseases cluster in families? A systematic review and meta-analysis |
title | How do autoimmune diseases cluster in families? A systematic review and meta-analysis |
title_full | How do autoimmune diseases cluster in families? A systematic review and meta-analysis |
title_fullStr | How do autoimmune diseases cluster in families? A systematic review and meta-analysis |
title_full_unstemmed | How do autoimmune diseases cluster in families? A systematic review and meta-analysis |
title_short | How do autoimmune diseases cluster in families? A systematic review and meta-analysis |
title_sort | how do autoimmune diseases cluster in families? a systematic review and meta-analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655934/ https://www.ncbi.nlm.nih.gov/pubmed/23497011 http://dx.doi.org/10.1186/1741-7015-11-73 |
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