HMGB1 Accelerates Alveolar Epithelial Repair via an IL-1β- and αvβ6 Integrin-dependent Activation of TGF-β1

High mobility group box 1 (HMGB1) protein is a danger-signaling molecule, known to activate an inflammatory response via TLR4 and RAGE. HMGB1 can be either actively secreted or passively released from damaged alveolar epithelial cells. Previous studies have shown that IL-1β, a critical mediator acut...

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Detalles Bibliográficos
Autores principales: Pittet, Jean-François, Koh, Hidefumi, Fang, Xiaohui, Iles, Karen, Christiaans, Sarah, Anjun, Naseem, Wagener, Brant M., Park, Dae Won, Zmijewski, Jaroslaw W., Matthay, Michael A., Roux, Jérémie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655948/
https://www.ncbi.nlm.nih.gov/pubmed/23696858
http://dx.doi.org/10.1371/journal.pone.0063907

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655948/
https://www.ncbi.nlm.nih.gov/pubmed/23696858
http://dx.doi.org/10.1371/journal.pone.0063907

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