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Disrupted Causal Connectivity in Mesial Temporal Lobe Epilepsy

Although mesial temporal lobe epilepsy (mTLE) is characterized by the pathological changes in mesial temporal lobe, function alteration was also found in extratemporal regions. Our aim is to investigate the information flow between the epileptogenic zone (EZ) and other brain regions. Resting-state f...

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Autores principales: Ji, Gong-Jun, Zhang, Zhiqiang, Zhang, Han, Wang, Jue, Liu, Dong-Qiang, Zang, Yu-Feng, Liao, Wei, Lu, Guangming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655975/
https://www.ncbi.nlm.nih.gov/pubmed/23696798
http://dx.doi.org/10.1371/journal.pone.0063183
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author Ji, Gong-Jun
Zhang, Zhiqiang
Zhang, Han
Wang, Jue
Liu, Dong-Qiang
Zang, Yu-Feng
Liao, Wei
Lu, Guangming
author_facet Ji, Gong-Jun
Zhang, Zhiqiang
Zhang, Han
Wang, Jue
Liu, Dong-Qiang
Zang, Yu-Feng
Liao, Wei
Lu, Guangming
author_sort Ji, Gong-Jun
collection PubMed
description Although mesial temporal lobe epilepsy (mTLE) is characterized by the pathological changes in mesial temporal lobe, function alteration was also found in extratemporal regions. Our aim is to investigate the information flow between the epileptogenic zone (EZ) and other brain regions. Resting-state functional magnetic resonance imaging (RS-fMRI) data were recorded from 23 patients with left mTLE and matched controls. We first identified the potential EZ using the amplitude of low-frequency fluctuation (ALFF) of RS-fMRI signal, then performed voxel-wise Granger causality analysis between EZ and the whole brain. Relative to controls, patients demonstrated decreased driving effect from EZ to thalamus and basal ganglia, and increased feedback. Additionally, we found an altered causal relation between EZ and cortical networks (default mode network, limbic system, visual network and executive control network). The influence from EZ to right precuneus and brainstem negatively correlated with disease duration, whereas that from the right hippocampus, fusiform cortex, and lentiform nucleus to EZ showed positive correlation. These findings demonstrate widespread brain regions showing abnormal functional interaction with EZ. In addition, increased ALFF in EZ was positively correlated with the increased driving effect on EZ in patients, but not in controls. This finding suggests that the initiation of epileptic activity depends not only on EZ itself, but also on the activity emerging in large-scale macroscopic brain networks. Overall, this study suggests that the causal topological organization is disrupted in mTLE, providing valuable information to understand the pathophysiology of this disorder.
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spelling pubmed-36559752013-05-21 Disrupted Causal Connectivity in Mesial Temporal Lobe Epilepsy Ji, Gong-Jun Zhang, Zhiqiang Zhang, Han Wang, Jue Liu, Dong-Qiang Zang, Yu-Feng Liao, Wei Lu, Guangming PLoS One Research Article Although mesial temporal lobe epilepsy (mTLE) is characterized by the pathological changes in mesial temporal lobe, function alteration was also found in extratemporal regions. Our aim is to investigate the information flow between the epileptogenic zone (EZ) and other brain regions. Resting-state functional magnetic resonance imaging (RS-fMRI) data were recorded from 23 patients with left mTLE and matched controls. We first identified the potential EZ using the amplitude of low-frequency fluctuation (ALFF) of RS-fMRI signal, then performed voxel-wise Granger causality analysis between EZ and the whole brain. Relative to controls, patients demonstrated decreased driving effect from EZ to thalamus and basal ganglia, and increased feedback. Additionally, we found an altered causal relation between EZ and cortical networks (default mode network, limbic system, visual network and executive control network). The influence from EZ to right precuneus and brainstem negatively correlated with disease duration, whereas that from the right hippocampus, fusiform cortex, and lentiform nucleus to EZ showed positive correlation. These findings demonstrate widespread brain regions showing abnormal functional interaction with EZ. In addition, increased ALFF in EZ was positively correlated with the increased driving effect on EZ in patients, but not in controls. This finding suggests that the initiation of epileptic activity depends not only on EZ itself, but also on the activity emerging in large-scale macroscopic brain networks. Overall, this study suggests that the causal topological organization is disrupted in mTLE, providing valuable information to understand the pathophysiology of this disorder. Public Library of Science 2013-05-16 /pmc/articles/PMC3655975/ /pubmed/23696798 http://dx.doi.org/10.1371/journal.pone.0063183 Text en © 2013 Ji et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Ji, Gong-Jun
Zhang, Zhiqiang
Zhang, Han
Wang, Jue
Liu, Dong-Qiang
Zang, Yu-Feng
Liao, Wei
Lu, Guangming
Disrupted Causal Connectivity in Mesial Temporal Lobe Epilepsy
title Disrupted Causal Connectivity in Mesial Temporal Lobe Epilepsy
title_full Disrupted Causal Connectivity in Mesial Temporal Lobe Epilepsy
title_fullStr Disrupted Causal Connectivity in Mesial Temporal Lobe Epilepsy
title_full_unstemmed Disrupted Causal Connectivity in Mesial Temporal Lobe Epilepsy
title_short Disrupted Causal Connectivity in Mesial Temporal Lobe Epilepsy
title_sort disrupted causal connectivity in mesial temporal lobe epilepsy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655975/
https://www.ncbi.nlm.nih.gov/pubmed/23696798
http://dx.doi.org/10.1371/journal.pone.0063183
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