CD137 Is Induced by the CD40 Signal on Chronic Lymphocytic Leukemia B Cells and Transduces the Survival Signal via NF-κB Activation

CD137 is a member of the tumor necrosis factor receptor family that is expressed on activated T cells. This molecule provides a co-stimulatory signal that enhances the survival, and differentiation of cells, and has a crucial role in the development of CD8 cytotoxic T cells and anti-tumor immunity....

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Autores principales: Nakaima, Yukana, Watanabe, Ken, Koyama, Takatoshi, Miura, Osamu, Fukuda, Tetsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655981/
https://www.ncbi.nlm.nih.gov/pubmed/23696891
http://dx.doi.org/10.1371/journal.pone.0064425
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author Nakaima, Yukana
Watanabe, Ken
Koyama, Takatoshi
Miura, Osamu
Fukuda, Tetsuya
author_facet Nakaima, Yukana
Watanabe, Ken
Koyama, Takatoshi
Miura, Osamu
Fukuda, Tetsuya
author_sort Nakaima, Yukana
collection PubMed
description CD137 is a member of the tumor necrosis factor receptor family that is expressed on activated T cells. This molecule provides a co-stimulatory signal that enhances the survival, and differentiation of cells, and has a crucial role in the development of CD8 cytotoxic T cells and anti-tumor immunity. Here we report that CD137 expression is also induced on normal or malignant human B cells by CD40 ligation by its ligand CD154. This CD137 induction was more prominent in chronic lymphocytic leukemia (CLL) cells than in other types of B cells. CD137 stimulation on B cells by its ligand induced the nuclear translocation of p52 (a non-canonical NF-κB factor). In agreement with this finding, expression of the survival factor BCL-XL was upregulated. Consequently, the CD137 signal augmented the survival of CD154-stimulated CLL B cells in vitro. This unexpected induction of CD137 on B cells by CD40 signal may influence the clinical course of CLL.
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spelling pubmed-36559812013-05-21 CD137 Is Induced by the CD40 Signal on Chronic Lymphocytic Leukemia B Cells and Transduces the Survival Signal via NF-κB Activation Nakaima, Yukana Watanabe, Ken Koyama, Takatoshi Miura, Osamu Fukuda, Tetsuya PLoS One Research Article CD137 is a member of the tumor necrosis factor receptor family that is expressed on activated T cells. This molecule provides a co-stimulatory signal that enhances the survival, and differentiation of cells, and has a crucial role in the development of CD8 cytotoxic T cells and anti-tumor immunity. Here we report that CD137 expression is also induced on normal or malignant human B cells by CD40 ligation by its ligand CD154. This CD137 induction was more prominent in chronic lymphocytic leukemia (CLL) cells than in other types of B cells. CD137 stimulation on B cells by its ligand induced the nuclear translocation of p52 (a non-canonical NF-κB factor). In agreement with this finding, expression of the survival factor BCL-XL was upregulated. Consequently, the CD137 signal augmented the survival of CD154-stimulated CLL B cells in vitro. This unexpected induction of CD137 on B cells by CD40 signal may influence the clinical course of CLL. Public Library of Science 2013-05-16 /pmc/articles/PMC3655981/ /pubmed/23696891 http://dx.doi.org/10.1371/journal.pone.0064425 Text en © 2013 Nakaima et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Nakaima, Yukana
Watanabe, Ken
Koyama, Takatoshi
Miura, Osamu
Fukuda, Tetsuya
CD137 Is Induced by the CD40 Signal on Chronic Lymphocytic Leukemia B Cells and Transduces the Survival Signal via NF-κB Activation
title CD137 Is Induced by the CD40 Signal on Chronic Lymphocytic Leukemia B Cells and Transduces the Survival Signal via NF-κB Activation
title_full CD137 Is Induced by the CD40 Signal on Chronic Lymphocytic Leukemia B Cells and Transduces the Survival Signal via NF-κB Activation
title_fullStr CD137 Is Induced by the CD40 Signal on Chronic Lymphocytic Leukemia B Cells and Transduces the Survival Signal via NF-κB Activation
title_full_unstemmed CD137 Is Induced by the CD40 Signal on Chronic Lymphocytic Leukemia B Cells and Transduces the Survival Signal via NF-κB Activation
title_short CD137 Is Induced by the CD40 Signal on Chronic Lymphocytic Leukemia B Cells and Transduces the Survival Signal via NF-κB Activation
title_sort cd137 is induced by the cd40 signal on chronic lymphocytic leukemia b cells and transduces the survival signal via nf-κb activation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655981/
https://www.ncbi.nlm.nih.gov/pubmed/23696891
http://dx.doi.org/10.1371/journal.pone.0064425
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