Mutations in NA That Induced Low pH-Stability and Enhanced the Replication of Pandemic (H1N1) 2009 Influenza A Virus at an Early Stage of the Pandemic

An influenza A virus that originated in pigs caused a pandemic in 2009. The sialidase activity of the neuraminidase (NA) of previous pandemic influenza A viruses are stable at low pH (≤5). Here, we identified the amino acids responsible for this property. We found differences in low-pH stability at...

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Autores principales: Takahashi, Tadanobu, Song, Jiasheng, Suzuki, Takashi, Kawaoka, Yoshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655982/
https://www.ncbi.nlm.nih.gov/pubmed/23696893
http://dx.doi.org/10.1371/journal.pone.0064439
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author Takahashi, Tadanobu
Song, Jiasheng
Suzuki, Takashi
Kawaoka, Yoshihiro
author_facet Takahashi, Tadanobu
Song, Jiasheng
Suzuki, Takashi
Kawaoka, Yoshihiro
author_sort Takahashi, Tadanobu
collection PubMed
description An influenza A virus that originated in pigs caused a pandemic in 2009. The sialidase activity of the neuraminidase (NA) of previous pandemic influenza A viruses are stable at low pH (≤5). Here, we identified the amino acids responsible for this property. We found differences in low-pH stability at pH 5.0 among pandemic (H1N1) 2009 viruses, which enhanced the replication of these viruses. Low-pH-stable NA enhancement of virus replication may have contributed to the rapid worldwide spread and adaptation to humans of pandemic (H1N1) 2009 viruses during the early stages of the 2009 pandemic.
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spelling pubmed-36559822013-05-21 Mutations in NA That Induced Low pH-Stability and Enhanced the Replication of Pandemic (H1N1) 2009 Influenza A Virus at an Early Stage of the Pandemic Takahashi, Tadanobu Song, Jiasheng Suzuki, Takashi Kawaoka, Yoshihiro PLoS One Research Article An influenza A virus that originated in pigs caused a pandemic in 2009. The sialidase activity of the neuraminidase (NA) of previous pandemic influenza A viruses are stable at low pH (≤5). Here, we identified the amino acids responsible for this property. We found differences in low-pH stability at pH 5.0 among pandemic (H1N1) 2009 viruses, which enhanced the replication of these viruses. Low-pH-stable NA enhancement of virus replication may have contributed to the rapid worldwide spread and adaptation to humans of pandemic (H1N1) 2009 viruses during the early stages of the 2009 pandemic. Public Library of Science 2013-05-16 /pmc/articles/PMC3655982/ /pubmed/23696893 http://dx.doi.org/10.1371/journal.pone.0064439 Text en © 2013 Takahashi et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Takahashi, Tadanobu
Song, Jiasheng
Suzuki, Takashi
Kawaoka, Yoshihiro
Mutations in NA That Induced Low pH-Stability and Enhanced the Replication of Pandemic (H1N1) 2009 Influenza A Virus at an Early Stage of the Pandemic
title Mutations in NA That Induced Low pH-Stability and Enhanced the Replication of Pandemic (H1N1) 2009 Influenza A Virus at an Early Stage of the Pandemic
title_full Mutations in NA That Induced Low pH-Stability and Enhanced the Replication of Pandemic (H1N1) 2009 Influenza A Virus at an Early Stage of the Pandemic
title_fullStr Mutations in NA That Induced Low pH-Stability and Enhanced the Replication of Pandemic (H1N1) 2009 Influenza A Virus at an Early Stage of the Pandemic
title_full_unstemmed Mutations in NA That Induced Low pH-Stability and Enhanced the Replication of Pandemic (H1N1) 2009 Influenza A Virus at an Early Stage of the Pandemic
title_short Mutations in NA That Induced Low pH-Stability and Enhanced the Replication of Pandemic (H1N1) 2009 Influenza A Virus at an Early Stage of the Pandemic
title_sort mutations in na that induced low ph-stability and enhanced the replication of pandemic (h1n1) 2009 influenza a virus at an early stage of the pandemic
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655982/
https://www.ncbi.nlm.nih.gov/pubmed/23696893
http://dx.doi.org/10.1371/journal.pone.0064439
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