New insights into the protective power of platelets in malaria infection

Platelets, as well as regulating blood hemostasis, are an important component of the body’s defense against invading microbial pathogens. We previously reported that platelets protect during malaria infection by binding Plasmodium-infected erythrocytes (IE) and killing the parasite within. More rece...

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Detalles Bibliográficos
Autores principales: McMorran, Brendan J., Burgio, Gaetan, Foote, Simon J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Mini Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656011/
https://www.ncbi.nlm.nih.gov/pubmed/23710276
http://dx.doi.org/10.4161/cib.23653
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author McMorran, Brendan J.
Burgio, Gaetan
Foote, Simon J.
author_facet McMorran, Brendan J.
Burgio, Gaetan
Foote, Simon J.
author_sort McMorran, Brendan J.
collection PubMed
description Platelets, as well as regulating blood hemostasis, are an important component of the body’s defense against invading microbial pathogens. We previously reported that platelets protect during malaria infection by binding Plasmodium-infected erythrocytes (IE) and killing the parasite within. More recent studies have now revealed the platelet plasmocidal factor, platelet factor 4 (PF4) and the red cell-expressed Duffy-antigen molecule as the central players in the parasite killing activity of platelets.
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spelling pubmed-36560112013-05-24 New insights into the protective power of platelets in malaria infection McMorran, Brendan J. Burgio, Gaetan Foote, Simon J. Commun Integr Biol Mini Review Platelets, as well as regulating blood hemostasis, are an important component of the body’s defense against invading microbial pathogens. We previously reported that platelets protect during malaria infection by binding Plasmodium-infected erythrocytes (IE) and killing the parasite within. More recent studies have now revealed the platelet plasmocidal factor, platelet factor 4 (PF4) and the red cell-expressed Duffy-antigen molecule as the central players in the parasite killing activity of platelets. Landes Bioscience 2013-05-01 2013-05-01 /pmc/articles/PMC3656011/ /pubmed/23710276 http://dx.doi.org/10.4161/cib.23653 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Mini Review
McMorran, Brendan J.
Burgio, Gaetan
Foote, Simon J.
New insights into the protective power of platelets in malaria infection
title New insights into the protective power of platelets in malaria infection
title_full New insights into the protective power of platelets in malaria infection
title_fullStr New insights into the protective power of platelets in malaria infection
title_full_unstemmed New insights into the protective power of platelets in malaria infection
title_short New insights into the protective power of platelets in malaria infection
title_sort new insights into the protective power of platelets in malaria infection
topic Mini Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656011/
https://www.ncbi.nlm.nih.gov/pubmed/23710276
http://dx.doi.org/10.4161/cib.23653
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