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Nuclear envelope-associated dynein cooperates with Eg5 to drive prophase centrosome separation

Eg5 (kinesin-5) is a highly conserved microtubule motor protein, essential for centrosome separation and bipolar spindle assembly in human cells. Using an “in vitro” evolution approach, we generated human cancer cells that can grow in the complete absence of Eg5 activity. Characterization of these E...

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Detalles Bibliográficos
Autores principales: van Heesbeen, Roy G.H.P., Raaijmakers, Jonne A., Tanenbaum, Marvin E., Medema, René H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656018/
https://www.ncbi.nlm.nih.gov/pubmed/23713137
http://dx.doi.org/10.4161/cib.23841

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