Synthetically engineered rpb1 alleles altering RNA polymerase II carboxy terminal domain phosphorylation induce discrete morphogenetic defects in Schizosaccharomyces pombe

In this report the phenotypic effects of systematic site-directed mutations in the fission yeast RNA pol II carboxy terminal domain (CTD) are investigated. Remarkably, we find that alterations in CTD structure and/or phosphorylation result in distinct phenotypic changes related to morphogenetic cont...

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Detalles Bibliográficos
Autores principales: Hoffman, Kyle, Yoo, Haeyoung, Karagiannis, Jim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656022/
https://www.ncbi.nlm.nih.gov/pubmed/23710280
http://dx.doi.org/10.4161/cib.23954
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author Hoffman, Kyle
Yoo, Haeyoung
Karagiannis, Jim
author_facet Hoffman, Kyle
Yoo, Haeyoung
Karagiannis, Jim
author_sort Hoffman, Kyle
collection PubMed
description In this report the phenotypic effects of systematic site-directed mutations in the fission yeast RNA pol II carboxy terminal domain (CTD) are investigated. Remarkably, we find that alterations in CTD structure and/or phosphorylation result in distinct phenotypic changes related to morphogenetic control. A hypothesis based upon the concepts of “informational entropy” and “algorithmic transformation” is developed to explicate/rationalize these results.
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spelling pubmed-36560222013-05-24 Synthetically engineered rpb1 alleles altering RNA polymerase II carboxy terminal domain phosphorylation induce discrete morphogenetic defects in Schizosaccharomyces pombe Hoffman, Kyle Yoo, Haeyoung Karagiannis, Jim Commun Integr Biol Short Communication In this report the phenotypic effects of systematic site-directed mutations in the fission yeast RNA pol II carboxy terminal domain (CTD) are investigated. Remarkably, we find that alterations in CTD structure and/or phosphorylation result in distinct phenotypic changes related to morphogenetic control. A hypothesis based upon the concepts of “informational entropy” and “algorithmic transformation” is developed to explicate/rationalize these results. Landes Bioscience 2013-05-01 2013-04-09 /pmc/articles/PMC3656022/ /pubmed/23710280 http://dx.doi.org/10.4161/cib.23954 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Short Communication
Hoffman, Kyle
Yoo, Haeyoung
Karagiannis, Jim
Synthetically engineered rpb1 alleles altering RNA polymerase II carboxy terminal domain phosphorylation induce discrete morphogenetic defects in Schizosaccharomyces pombe
title Synthetically engineered rpb1 alleles altering RNA polymerase II carboxy terminal domain phosphorylation induce discrete morphogenetic defects in Schizosaccharomyces pombe
title_full Synthetically engineered rpb1 alleles altering RNA polymerase II carboxy terminal domain phosphorylation induce discrete morphogenetic defects in Schizosaccharomyces pombe
title_fullStr Synthetically engineered rpb1 alleles altering RNA polymerase II carboxy terminal domain phosphorylation induce discrete morphogenetic defects in Schizosaccharomyces pombe
title_full_unstemmed Synthetically engineered rpb1 alleles altering RNA polymerase II carboxy terminal domain phosphorylation induce discrete morphogenetic defects in Schizosaccharomyces pombe
title_short Synthetically engineered rpb1 alleles altering RNA polymerase II carboxy terminal domain phosphorylation induce discrete morphogenetic defects in Schizosaccharomyces pombe
title_sort synthetically engineered rpb1 alleles altering rna polymerase ii carboxy terminal domain phosphorylation induce discrete morphogenetic defects in schizosaccharomyces pombe
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656022/
https://www.ncbi.nlm.nih.gov/pubmed/23710280
http://dx.doi.org/10.4161/cib.23954
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