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RANKL/RANK/MMP-1 Molecular Triad Contributes to the Metastatic Phenotype of Breast and Prostate Cancer Cells In Vitro

The osteolytic nature of bone metastasis results from a tumor-driven increased bone resorption. Bone remodeling is orchestrated by the molecular triad RANK-RANKL-OPG. This process is dysregulated in bone metastases, mostly via induction of RANKL by tumor-derived factors. These factors increase expre...

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Detalles Bibliográficos
Autores principales:	Casimiro, Sandra, Mohammad, Khalid S., Pires, Ricardo, Tato-Costa, Joana, Alho, Irina, Teixeira, Rui, Carvalho, António, Ribeiro, Sofia, Lipton, Allan, Guise, Theresa A., Costa, Luis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656033/ https://www.ncbi.nlm.nih.gov/pubmed/23696795 http://dx.doi.org/10.1371/journal.pone.0063153

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