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Uracil DNA Glycosylase Counteracts APOBEC3G-Induced Hypermutation of Hepatitis B Viral Genomes: Excision Repair of Covalently Closed Circular DNA

The covalently closed circular DNA (cccDNA) of the hepatitis B virus (HBV) plays an essential role in chronic hepatitis. The cellular repair system is proposed to convert cytoplasmic nucleocapsid (NC) DNA (partially double-stranded DNA) into cccDNA in the nucleus. Recently, antiviral cytidine deamin...

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Detalles Bibliográficos
Autores principales:	Kitamura, Kouichi, Wang, Zhe, Chowdhury, Sajeda, Simadu, Miyuki, Koura, Miki, Muramatsu, Masamichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656096/ https://www.ncbi.nlm.nih.gov/pubmed/23696735 http://dx.doi.org/10.1371/journal.ppat.1003361

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