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Two Misfolding Routes for the Prion Protein around pH 4.5

Using molecular dynamics simulations, we show that the prion protein (PrP) exhibits a dual behavior, with two possible transition routes, upon protonation of H187 around pH 4.5, which mimics specific conditions encountered in endosomes. Our results suggest a picture in which the protonated imidazole...

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Detalles Bibliográficos
Autores principales: Garrec, Julian, Tavernelli, Ivano, Rothlisberger, Ursula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656106/
https://www.ncbi.nlm.nih.gov/pubmed/23696721
http://dx.doi.org/10.1371/journal.pcbi.1003057