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Pasteurella Multocida Toxin Prevents Osteoblast Differentiation by Transactivation of the MAP-Kinase Cascade via the Gα(q/11) - p63RhoGEF - RhoA Axis

The 146-kDa Pasteurella multocida toxin (PMT) is the main virulence factor to induce P. multocida-associated progressive atrophic rhinitis in various animals. PMT leads to a destruction of nasal turbinate bones implicating an effect of the toxin on osteoblasts and/or osteoclasts. The toxin induces c...

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Detalles Bibliográficos
Autores principales:	Siegert, Peter, Schmidt, Gudula, Papatheodorou, Panagiotis, Wieland, Thomas, Aktories, Klaus, Orth, Joachim H. C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656108/ https://www.ncbi.nlm.nih.gov/pubmed/23696743 http://dx.doi.org/10.1371/journal.ppat.1003385

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