A Mechanistic Understanding of Allosteric Immune Escape Pathways in the HIV-1 Envelope Glycoprotein

The HIV-1 envelope (Env) spike, which consists of a compact, heterodimeric trimer of the glycoproteins gp120 and gp41, is the target of neutralizing antibodies. However, the high mutation rate of HIV-1 and plasticity of Env facilitates viral evasion from neutralizing antibodies through various mecha...

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Detalles Bibliográficos
Autores principales: Sethi, Anurag, Tian, Jianhui, Derdeyn, Cynthia A., Korber, Bette, Gnanakaran, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656115/
https://www.ncbi.nlm.nih.gov/pubmed/23696718
http://dx.doi.org/10.1371/journal.pcbi.1003046

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656115/
https://www.ncbi.nlm.nih.gov/pubmed/23696718
http://dx.doi.org/10.1371/journal.pcbi.1003046

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