ATM–Dependent MiR-335 Targets CtIP and Modulates the DNA Damage Response

ATM plays a critical role in cellular responses to DNA double-strand breaks (DSBs). We describe a new ATM–mediated DSB–induced DNA damage response pathway involving microRNA (miRNA): irradiation (IR)-induced DSBs activate ATM, which leads to the downregulation of miR-335, a miRNA that targets CtIP,...

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Detalles Bibliográficos
Autores principales: Martin, Nathan T., Nakamura, Kotoka, Davies, Robert, Nahas, Shareef A., Brown, Christina, Tunuguntla, Rashmi, Gatti, Richard A., Hu, Hailiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656122/
https://www.ncbi.nlm.nih.gov/pubmed/23696749
http://dx.doi.org/10.1371/journal.pgen.1003505

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