Differential Roles of Orexin Receptors in the Regulation of Sleep/Wakefulness

Orexin A and orexin B are hypothalamic neuropeptides that play critical roles in the regulation of sleep/wakefulness, as well as in a variety of physiological functions such as emotion, reward, and energy homeostasis. The actions of orexins are mediated by two receptors, orexin 1 (OX1R) and orexin 2...

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Autores principales: Mieda, Michihiro, Tsujino, Natsuko, Sakurai, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656340/
https://www.ncbi.nlm.nih.gov/pubmed/23730297
http://dx.doi.org/10.3389/fendo.2013.00057
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author Mieda, Michihiro
Tsujino, Natsuko
Sakurai, Takeshi
author_facet Mieda, Michihiro
Tsujino, Natsuko
Sakurai, Takeshi
author_sort Mieda, Michihiro
collection PubMed
description Orexin A and orexin B are hypothalamic neuropeptides that play critical roles in the regulation of sleep/wakefulness, as well as in a variety of physiological functions such as emotion, reward, and energy homeostasis. The actions of orexins are mediated by two receptors, orexin 1 (OX1R) and orexin 2 (OX2R) receptors. OX1R and OX2R show partly overlapping but distinct distributions throughout the central nervous system, suggesting their differential roles. This review presents and discusses the current knowledge concerning the physiological roles of each orexin receptor subtype, focusing on the regulation of sleep/wakefulness.
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spelling pubmed-36563402013-05-31 Differential Roles of Orexin Receptors in the Regulation of Sleep/Wakefulness Mieda, Michihiro Tsujino, Natsuko Sakurai, Takeshi Front Endocrinol (Lausanne) Endocrinology Orexin A and orexin B are hypothalamic neuropeptides that play critical roles in the regulation of sleep/wakefulness, as well as in a variety of physiological functions such as emotion, reward, and energy homeostasis. The actions of orexins are mediated by two receptors, orexin 1 (OX1R) and orexin 2 (OX2R) receptors. OX1R and OX2R show partly overlapping but distinct distributions throughout the central nervous system, suggesting their differential roles. This review presents and discusses the current knowledge concerning the physiological roles of each orexin receptor subtype, focusing on the regulation of sleep/wakefulness. Frontiers Media S.A. 2013-05-16 /pmc/articles/PMC3656340/ /pubmed/23730297 http://dx.doi.org/10.3389/fendo.2013.00057 Text en Copyright © 2013 Mieda, Tsujino and Sakurai. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Endocrinology
Mieda, Michihiro
Tsujino, Natsuko
Sakurai, Takeshi
Differential Roles of Orexin Receptors in the Regulation of Sleep/Wakefulness
title Differential Roles of Orexin Receptors in the Regulation of Sleep/Wakefulness
title_full Differential Roles of Orexin Receptors in the Regulation of Sleep/Wakefulness
title_fullStr Differential Roles of Orexin Receptors in the Regulation of Sleep/Wakefulness
title_full_unstemmed Differential Roles of Orexin Receptors in the Regulation of Sleep/Wakefulness
title_short Differential Roles of Orexin Receptors in the Regulation of Sleep/Wakefulness
title_sort differential roles of orexin receptors in the regulation of sleep/wakefulness
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656340/
https://www.ncbi.nlm.nih.gov/pubmed/23730297
http://dx.doi.org/10.3389/fendo.2013.00057
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