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Direct Retino-Raphe Projection Alters Serotonergic Tone and Affective Behavior

Light is a powerful modulator of higher-order cognitive processes such as mood but it remains unclear which neural circuits mediate the impact of light on affective behavior. We found that light deprivation produces a depressive-like behavioral state that is reversed by activation of direct retinal...

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Detalles Bibliográficos
Autores principales: Ren, Chaoran, Luan, Liju, Wui-Man Lau, Benson, Huang, Xin, Yang, Jian, Zhou, Yuan, Wu, Xihong, Gao, Jie, Pickard, Gary E, So, Kwok-Fai, Pu, Mingliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656380/
https://www.ncbi.nlm.nih.gov/pubmed/23370156
http://dx.doi.org/10.1038/npp.2013.35
Descripción
Sumario:Light is a powerful modulator of higher-order cognitive processes such as mood but it remains unclear which neural circuits mediate the impact of light on affective behavior. We found that light deprivation produces a depressive-like behavioral state that is reversed by activation of direct retinal signals to the serotonergic dorsal raphe nucleus (DRN) in a manner equivalent to treatment with the selective serotonin reuptake inhibitor fluoxetine. Surprisingly, the DRN-projecting retinal ganglion cells (RGCs) are indistinguishable from the classic alpha/Y-like RGC type that contributes to image-forming visual pathways. Silencing RGC firing or specific immunotoxin ablation of DRN-projecting RGCs increased depressive-like behavior and reduced serotonin levels in the DRN. Serotonin has a key role in the pathophysiology of depression, and these results demonstrate that retino-raphe signals modulate DRN serotonergic tone and affective behavior.