Glutamine supports pancreatic cancer growth through a Kras-regulated metabolic pathway

Cancer cells exhibit metabolic dependencies that distinguish them from their normal counterparts(1). Among these addictions is an increased utilization of the amino acid glutamine (Gln) to fuel anabolic processes(2). Indeed, the spectrum of Gln-dependent tumors and the mechanisms whereby Gln support...

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Detalles Bibliográficos
Autores principales: Son, Jaekyoung, Lyssiotis, Costas A., Ying, Haoqiang, Wang, Xiaoxu, Hua, Sujun, Ligorio, Matteo, Perera, Rushika M., Ferrone, Cristina R., Mullarky, Edouard, Shyh-Chang, Ng, Kang, Ya’an, Fleming, Jason B., Bardeesy, Nabeel, Asara, John M., Haigis, Marcia C., DePinho, Ronald A., Cantley, Lewis C., Kimmelman, Alec C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656466/
https://www.ncbi.nlm.nih.gov/pubmed/23535601
http://dx.doi.org/10.1038/nature12040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656466/
https://www.ncbi.nlm.nih.gov/pubmed/23535601
http://dx.doi.org/10.1038/nature12040

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