The low frequency of Y chromosome microdeletions in subfertile males in a Sinhalese population of Sri Lanka

AIMS: This study was designed to determine the prevalence of azoospermia factor (AZF) microdeletions on the Y chromosome in Sri Lankan Sinhalese infertile men with azoospermia and severe oligozoospermia. SETTINGS AND DESIGN: The patient group was 207 karyotypically normal infertile Sinhalese males....

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Detalles Bibliográficos
Autores principales: Wettasinghe, Tithila Kalum, Jayasekara, Rohan W., Dissanayake, Vajira H. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656521/
https://www.ncbi.nlm.nih.gov/pubmed/23716940
http://dx.doi.org/10.4103/0971-6866.107985
Descripción
Sumario:AIMS: This study was designed to determine the prevalence of azoospermia factor (AZF) microdeletions on the Y chromosome in Sri Lankan Sinhalese infertile men with azoospermia and severe oligozoospermia. SETTINGS AND DESIGN: The patient group was 207 karyotypically normal infertile Sinhalese males. MATERIALS AND METHODS: The presence of 13 sequence-tagged site (STS) markers in the AZF region was tested using multiplex polymerase chain reaction (M-PCR). One hundred and twenty unselected men were also studied as a control group. RESULTS: Three (1.5%) had classic Y chromosome microdeletions in the AZFc sub-region. CONCLUSIONS: These results suggest a much lower Y chromosome microdeletion frequency than previously thought, even among a strictly selected group of sub-fertile males in Sri Lanka.

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