A novel 11;18 translocation in a case of acute myeloid leukemia with maturation

Acute myeloid leukemia with maturation (AML-M2) is associated with the 8;21 translocation. For the first time in an adult patient with AML-M2, a novel unbalanced translocation involving the short arm of chromosome 11 and long arm of chromosome18 with new breakpoints is presented. CD82 on band 11p11....

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Autores principales: Sandhya, Devi G., Ahmed, Faiq, Khadke, Kavita, Murthy, Sudha S., Rajappa, Senthil J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656533/
https://www.ncbi.nlm.nih.gov/pubmed/23716952
http://dx.doi.org/10.4103/0971-6866.108050
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author Sandhya, Devi G.
Ahmed, Faiq
Khadke, Kavita
Murthy, Sudha S.
Rajappa, Senthil J.
author_facet Sandhya, Devi G.
Ahmed, Faiq
Khadke, Kavita
Murthy, Sudha S.
Rajappa, Senthil J.
author_sort Sandhya, Devi G.
collection PubMed
description Acute myeloid leukemia with maturation (AML-M2) is associated with the 8;21 translocation. For the first time in an adult patient with AML-M2, a novel unbalanced translocation involving the short arm of chromosome 11 and long arm of chromosome18 with new breakpoints is presented. CD82 on band 11p11.2 and GATA 6 on 18q11.2 may play a role in the pathogenesis of de novo AML M2. The report with translocation (11;18)(p11.2;q11.2), as the sole cytogenetic abnormality provides more data on the leukemogenesis of de novo AML M2.
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spelling pubmed-36565332013-05-28 A novel 11;18 translocation in a case of acute myeloid leukemia with maturation Sandhya, Devi G. Ahmed, Faiq Khadke, Kavita Murthy, Sudha S. Rajappa, Senthil J. Indian J Hum Genet Case Report Acute myeloid leukemia with maturation (AML-M2) is associated with the 8;21 translocation. For the first time in an adult patient with AML-M2, a novel unbalanced translocation involving the short arm of chromosome 11 and long arm of chromosome18 with new breakpoints is presented. CD82 on band 11p11.2 and GATA 6 on 18q11.2 may play a role in the pathogenesis of de novo AML M2. The report with translocation (11;18)(p11.2;q11.2), as the sole cytogenetic abnormality provides more data on the leukemogenesis of de novo AML M2. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3656533/ /pubmed/23716952 http://dx.doi.org/10.4103/0971-6866.108050 Text en Copyright: © Indian Journal of Human Genetics http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Sandhya, Devi G.
Ahmed, Faiq
Khadke, Kavita
Murthy, Sudha S.
Rajappa, Senthil J.
A novel 11;18 translocation in a case of acute myeloid leukemia with maturation
title A novel 11;18 translocation in a case of acute myeloid leukemia with maturation
title_full A novel 11;18 translocation in a case of acute myeloid leukemia with maturation
title_fullStr A novel 11;18 translocation in a case of acute myeloid leukemia with maturation
title_full_unstemmed A novel 11;18 translocation in a case of acute myeloid leukemia with maturation
title_short A novel 11;18 translocation in a case of acute myeloid leukemia with maturation
title_sort novel 11;18 translocation in a case of acute myeloid leukemia with maturation
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656533/
https://www.ncbi.nlm.nih.gov/pubmed/23716952
http://dx.doi.org/10.4103/0971-6866.108050
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