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Neuropathology of brain metastases

Metastatic tumors are the most common neoplasms encountered in the central nervous system (CNS), and continue to be major cause for mortality and morbidity. Macroscopic features and corresponding radiological findings can be diagnostic in majority of the cases, however, microscopic evaluation would...

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Autores principales: Pekmezci, Melike, Perry, Arie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656562/
https://www.ncbi.nlm.nih.gov/pubmed/23717796
http://dx.doi.org/10.4103/2152-7806.111302
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author Pekmezci, Melike
Perry, Arie
author_facet Pekmezci, Melike
Perry, Arie
author_sort Pekmezci, Melike
collection PubMed
description Metastatic tumors are the most common neoplasms encountered in the central nervous system (CNS), and continue to be major cause for mortality and morbidity. Macroscopic features and corresponding radiological findings can be diagnostic in majority of the cases, however, microscopic evaluation would be necessary when the differential diagnosis includes a primary CNS tumor, unknown primary tumor site, and when the resection of the tumor is either considered therapeutic or palliative. The first step in the diagnosis of a metastatic brain lesion is to exclude a primary CNS tumor, followed by verification or identification of the primary tumor and the site. Although general approach to a metastatic lesion from an unknown primary tumor is the same everywhere else, there are slight variations for the metastatic lesions in the CNS versus other regions. When morphological features are not enough to establish a definitive diagnosis, additional studies including immunohistochemical stains are applied. With the expending immunohistochemical armamentarium for pathologists, more accurate assessments are possible even in cases of unknown primary tumor. This review summarizes the diagnostic approach to CNS metastases, immunohistochemical assessment of neoplasm of unknown primary, and primary CNS lesions entering in the differential diagnosis of metastases.
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spelling pubmed-36565622013-05-28 Neuropathology of brain metastases Pekmezci, Melike Perry, Arie Surg Neurol Int Surgical Neurology International: Neuro-Oncology Metastatic tumors are the most common neoplasms encountered in the central nervous system (CNS), and continue to be major cause for mortality and morbidity. Macroscopic features and corresponding radiological findings can be diagnostic in majority of the cases, however, microscopic evaluation would be necessary when the differential diagnosis includes a primary CNS tumor, unknown primary tumor site, and when the resection of the tumor is either considered therapeutic or palliative. The first step in the diagnosis of a metastatic brain lesion is to exclude a primary CNS tumor, followed by verification or identification of the primary tumor and the site. Although general approach to a metastatic lesion from an unknown primary tumor is the same everywhere else, there are slight variations for the metastatic lesions in the CNS versus other regions. When morphological features are not enough to establish a definitive diagnosis, additional studies including immunohistochemical stains are applied. With the expending immunohistochemical armamentarium for pathologists, more accurate assessments are possible even in cases of unknown primary tumor. This review summarizes the diagnostic approach to CNS metastases, immunohistochemical assessment of neoplasm of unknown primary, and primary CNS lesions entering in the differential diagnosis of metastases. Medknow Publications & Media Pvt Ltd 2013-05-02 /pmc/articles/PMC3656562/ /pubmed/23717796 http://dx.doi.org/10.4103/2152-7806.111302 Text en Copyright: © 2013 Pekmezci M http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Surgical Neurology International: Neuro-Oncology
Pekmezci, Melike
Perry, Arie
Neuropathology of brain metastases
title Neuropathology of brain metastases
title_full Neuropathology of brain metastases
title_fullStr Neuropathology of brain metastases
title_full_unstemmed Neuropathology of brain metastases
title_short Neuropathology of brain metastases
title_sort neuropathology of brain metastases
topic Surgical Neurology International: Neuro-Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656562/
https://www.ncbi.nlm.nih.gov/pubmed/23717796
http://dx.doi.org/10.4103/2152-7806.111302
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