Cargando…

Elevated CSF histamine levels in multiple sclerosis patients

BACKGROUND: Histamine is an ubiquitous inflammatory mediator of numerous physiological processes. Histamine and its receptors have been implicated in multiple sclerosis (MS) disease pathogenesis. We prospectively enrolled 36 MS patients and 19 age and gender-matched healthy volunteers for cerebrospi...

Descripción completa

Detalles Bibliográficos
Autores principales: Kallweit, Ulf, Aritake, Kosuke, Bassetti, Claudio L, Blumenthal, Stephan, Hayaishi, Osamu, Linnebank, Michael, Baumann, Christian R, Urade, Yoshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656773/
https://www.ncbi.nlm.nih.gov/pubmed/23659456
http://dx.doi.org/10.1186/2045-8118-10-19
_version_ 1782270046598332416
author Kallweit, Ulf
Aritake, Kosuke
Bassetti, Claudio L
Blumenthal, Stephan
Hayaishi, Osamu
Linnebank, Michael
Baumann, Christian R
Urade, Yoshihiro
author_facet Kallweit, Ulf
Aritake, Kosuke
Bassetti, Claudio L
Blumenthal, Stephan
Hayaishi, Osamu
Linnebank, Michael
Baumann, Christian R
Urade, Yoshihiro
author_sort Kallweit, Ulf
collection PubMed
description BACKGROUND: Histamine is an ubiquitous inflammatory mediator of numerous physiological processes. Histamine and its receptors have been implicated in multiple sclerosis (MS) disease pathogenesis. We prospectively enrolled 36 MS patients and 19 age and gender-matched healthy volunteers for cerebrospinal fluid (CSF) histamine analysis. FINDINGS: CSF histamine levels in MS patient samples were significantly higher (median: 35.6 pg/ml) than in controls (median: 5.5 pg/ml; Beta = 0.525, p < 0.001). In addition, histamine increased with age (Pearson’s correlation, p < 0.003). CONCLUSIONS: Histamine may be an important factor for both the initiation and maintenance of chronic inflammatory diseases of the central nervous system. Our observation encourages a deeper investigation of the role of histamine in MS.
format Online
Article
Text
id pubmed-3656773
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-36567732013-05-18 Elevated CSF histamine levels in multiple sclerosis patients Kallweit, Ulf Aritake, Kosuke Bassetti, Claudio L Blumenthal, Stephan Hayaishi, Osamu Linnebank, Michael Baumann, Christian R Urade, Yoshihiro Fluids Barriers CNS Short Paper BACKGROUND: Histamine is an ubiquitous inflammatory mediator of numerous physiological processes. Histamine and its receptors have been implicated in multiple sclerosis (MS) disease pathogenesis. We prospectively enrolled 36 MS patients and 19 age and gender-matched healthy volunteers for cerebrospinal fluid (CSF) histamine analysis. FINDINGS: CSF histamine levels in MS patient samples were significantly higher (median: 35.6 pg/ml) than in controls (median: 5.5 pg/ml; Beta = 0.525, p < 0.001). In addition, histamine increased with age (Pearson’s correlation, p < 0.003). CONCLUSIONS: Histamine may be an important factor for both the initiation and maintenance of chronic inflammatory diseases of the central nervous system. Our observation encourages a deeper investigation of the role of histamine in MS. BioMed Central 2013-05-09 /pmc/articles/PMC3656773/ /pubmed/23659456 http://dx.doi.org/10.1186/2045-8118-10-19 Text en Copyright © 2013 Kallweit et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Paper
Kallweit, Ulf
Aritake, Kosuke
Bassetti, Claudio L
Blumenthal, Stephan
Hayaishi, Osamu
Linnebank, Michael
Baumann, Christian R
Urade, Yoshihiro
Elevated CSF histamine levels in multiple sclerosis patients
title Elevated CSF histamine levels in multiple sclerosis patients
title_full Elevated CSF histamine levels in multiple sclerosis patients
title_fullStr Elevated CSF histamine levels in multiple sclerosis patients
title_full_unstemmed Elevated CSF histamine levels in multiple sclerosis patients
title_short Elevated CSF histamine levels in multiple sclerosis patients
title_sort elevated csf histamine levels in multiple sclerosis patients
topic Short Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656773/
https://www.ncbi.nlm.nih.gov/pubmed/23659456
http://dx.doi.org/10.1186/2045-8118-10-19
work_keys_str_mv AT kallweitulf elevatedcsfhistaminelevelsinmultiplesclerosispatients
AT aritakekosuke elevatedcsfhistaminelevelsinmultiplesclerosispatients
AT bassetticlaudiol elevatedcsfhistaminelevelsinmultiplesclerosispatients
AT blumenthalstephan elevatedcsfhistaminelevelsinmultiplesclerosispatients
AT hayaishiosamu elevatedcsfhistaminelevelsinmultiplesclerosispatients
AT linnebankmichael elevatedcsfhistaminelevelsinmultiplesclerosispatients
AT baumannchristianr elevatedcsfhistaminelevelsinmultiplesclerosispatients
AT uradeyoshihiro elevatedcsfhistaminelevelsinmultiplesclerosispatients