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Elevated CSF histamine levels in multiple sclerosis patients
BACKGROUND: Histamine is an ubiquitous inflammatory mediator of numerous physiological processes. Histamine and its receptors have been implicated in multiple sclerosis (MS) disease pathogenesis. We prospectively enrolled 36 MS patients and 19 age and gender-matched healthy volunteers for cerebrospi...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656773/ https://www.ncbi.nlm.nih.gov/pubmed/23659456 http://dx.doi.org/10.1186/2045-8118-10-19 |
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author | Kallweit, Ulf Aritake, Kosuke Bassetti, Claudio L Blumenthal, Stephan Hayaishi, Osamu Linnebank, Michael Baumann, Christian R Urade, Yoshihiro |
author_facet | Kallweit, Ulf Aritake, Kosuke Bassetti, Claudio L Blumenthal, Stephan Hayaishi, Osamu Linnebank, Michael Baumann, Christian R Urade, Yoshihiro |
author_sort | Kallweit, Ulf |
collection | PubMed |
description | BACKGROUND: Histamine is an ubiquitous inflammatory mediator of numerous physiological processes. Histamine and its receptors have been implicated in multiple sclerosis (MS) disease pathogenesis. We prospectively enrolled 36 MS patients and 19 age and gender-matched healthy volunteers for cerebrospinal fluid (CSF) histamine analysis. FINDINGS: CSF histamine levels in MS patient samples were significantly higher (median: 35.6 pg/ml) than in controls (median: 5.5 pg/ml; Beta = 0.525, p < 0.001). In addition, histamine increased with age (Pearson’s correlation, p < 0.003). CONCLUSIONS: Histamine may be an important factor for both the initiation and maintenance of chronic inflammatory diseases of the central nervous system. Our observation encourages a deeper investigation of the role of histamine in MS. |
format | Online Article Text |
id | pubmed-3656773 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-36567732013-05-18 Elevated CSF histamine levels in multiple sclerosis patients Kallweit, Ulf Aritake, Kosuke Bassetti, Claudio L Blumenthal, Stephan Hayaishi, Osamu Linnebank, Michael Baumann, Christian R Urade, Yoshihiro Fluids Barriers CNS Short Paper BACKGROUND: Histamine is an ubiquitous inflammatory mediator of numerous physiological processes. Histamine and its receptors have been implicated in multiple sclerosis (MS) disease pathogenesis. We prospectively enrolled 36 MS patients and 19 age and gender-matched healthy volunteers for cerebrospinal fluid (CSF) histamine analysis. FINDINGS: CSF histamine levels in MS patient samples were significantly higher (median: 35.6 pg/ml) than in controls (median: 5.5 pg/ml; Beta = 0.525, p < 0.001). In addition, histamine increased with age (Pearson’s correlation, p < 0.003). CONCLUSIONS: Histamine may be an important factor for both the initiation and maintenance of chronic inflammatory diseases of the central nervous system. Our observation encourages a deeper investigation of the role of histamine in MS. BioMed Central 2013-05-09 /pmc/articles/PMC3656773/ /pubmed/23659456 http://dx.doi.org/10.1186/2045-8118-10-19 Text en Copyright © 2013 Kallweit et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Paper Kallweit, Ulf Aritake, Kosuke Bassetti, Claudio L Blumenthal, Stephan Hayaishi, Osamu Linnebank, Michael Baumann, Christian R Urade, Yoshihiro Elevated CSF histamine levels in multiple sclerosis patients |
title | Elevated CSF histamine levels in multiple sclerosis patients |
title_full | Elevated CSF histamine levels in multiple sclerosis patients |
title_fullStr | Elevated CSF histamine levels in multiple sclerosis patients |
title_full_unstemmed | Elevated CSF histamine levels in multiple sclerosis patients |
title_short | Elevated CSF histamine levels in multiple sclerosis patients |
title_sort | elevated csf histamine levels in multiple sclerosis patients |
topic | Short Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656773/ https://www.ncbi.nlm.nih.gov/pubmed/23659456 http://dx.doi.org/10.1186/2045-8118-10-19 |
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