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Semi-Supervised Prediction of SH2-Peptide Interactions from Imbalanced High-Throughput Data

Src homology 2 (SH2) domains are the largest family of the peptide-recognition modules (PRMs) that bind to phosphotyrosine containing peptides. Knowledge about binding partners of SH2-domains is key for a deeper understanding of different cellular processes. Given the high binding specificity of SH2...

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Detalles Bibliográficos
Autores principales: Kundu, Kousik, Costa, Fabrizio, Huber, Michael, Reth, Michael, Backofen, Rolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656881/
https://www.ncbi.nlm.nih.gov/pubmed/23690949
http://dx.doi.org/10.1371/journal.pone.0062732