Cargando…

Tobacco Smoking Leads to Extensive Genome-Wide Changes in DNA Methylation

Environmental factors such as tobacco smoking may have long-lasting effects on DNA methylation patterns, which might lead to changes in gene expression and in a broader context to the development or progression of various diseases. We conducted an epigenome-wide association study (EWAs) comparing cu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zeilinger, Sonja, Kühnel, Brigitte, Klopp, Norman, Baurecht, Hansjörg, Kleinschmidt, Anja, Gieger, Christian, Weidinger, Stephan, Lattka, Eva, Adamski, Jerzy, Peters, Annette, Strauch, Konstantin, Waldenberger, Melanie, Illig, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656907/ https://www.ncbi.nlm.nih.gov/pubmed/23691101 http://dx.doi.org/10.1371/journal.pone.0063812

Ejemplares similares

Metabolite profiling reveals new insights into the regulation of serum urate in humans
por: Albrecht, Eva, et al.
Publicado: (2013)

Epigenetics meets metabolomics: an epigenome-wide association study with blood serum metabolic traits
por: Petersen, Ann-Kristin, et al.
Publicado: (2014)

Compare and Contrast Meta Analysis (CCMA): A Method for Identification of Pleiotropic Loci in Genome-Wide Association Studies
por: Baurecht, Hansjörg, et al.
Publicado: (2016)

Mitochondrial GWA Analysis of Lipid Profile Identifies Genetic Variants to Be Associated with HDL Cholesterol and Triglyceride Levels
por: Flaquer, Antònia, et al.
Publicado: (2015)

pulver: an R package for parallel ultra-rapid p-value computation for linear regression interaction terms
por: Molnos, Sophie, et al.
Publicado: (2017)

The Pharmacogenetic Footprint of ACE Inhibition: A Population-Based Metabolomics Study
por: Altmaier, Elisabeth, et al.
Publicado: (2016)

The metabolic network coherence of human transcriptomes is associated with genetic variation at the cadherin 18 locus
por: Schlicht, Kristina, et al.
Publicado: (2019)

Metabolomics approach reveals effects of antihypertensives and lipid-lowering drugs on the human metabolism
por: Altmaier, Elisabeth, et al.
Publicado: (2014)

On the potential of models for location and scale for genome-wide DNA methylation data
por: Wahl, Simone, et al.
Publicado: (2014)

Are Epigenetic Factors Implicated in Chronic Widespread Pain?
por: Burri, Andrea, et al.
Publicado: (2016)

Genetic variants including markers from the exome chip and metabolite traits of type 2 diabetes
por: Jäger, Susanne, et al.
Publicado: (2017)

Metabolic Profiling Reveals Distinct Variations Linked to Nicotine Consumption in Humans — First Results from the KORA Study
por: Wang-Sattler, Rui, et al.
Publicado: (2008)

Human serum metabolic profiles are age dependent
por: Yu, Zhonghao, et al.
Publicado: (2012)

The dynamics of smoking-related disturbed methylation: a two time-point study of methylation change in smokers, non-smokers and former smokers
por: Wilson, Rory, et al.
Publicado: (2017)

The Human Blood Metabolome-Transcriptome Interface
por: Bartel, Jörg, et al.
Publicado: (2015)

Discovery of Sexual Dimorphisms in Metabolic and Genetic Biomarkers
por: Mittelstrass, Kirstin, et al.
Publicado: (2011)

Network reconstruction for trans acting genetic loci using multi-omics data and prior information
por: Hawe, Johann S., et al.
Publicado: (2022)

Mitochondrial Genetic Variants Identified to Be Associated with BMI in Adults
por: Flaquer, Antònia, et al.
Publicado: (2014)

Host genetic factors related to innate immunity, environmental sensing and cellular functions are associated with human skin microbiota
por: Moitinho-Silva, Lucas, et al.
Publicado: (2022)

Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits
por: Zaghlool, Shaza B., et al.
Publicado: (2020)

Network-based SNP meta-analysis identifies joint and disjoint genetic features across common human diseases
por: Arnold, Matthias, et al.
Publicado: (2012)

Association between DNA Methylation in Whole Blood and Measures of Glucose Metabolism: KORA F4 Study
por: Kriebel, Jennifer, et al.
Publicado: (2016)

Characterization of missing values in untargeted MS-based metabolomics data and evaluation of missing data handling strategies
por: Do, Kieu Trinh, et al.
Publicado: (2018)

Genome-Wide Scan on Total Serum IgE Levels Identifies FCER1A as Novel Susceptibility Locus
por: Weidinger, Stephan, et al.
Publicado: (2008)

Long term conservation of human metabolic phenotypes and link to heritability
por: Yousri, Noha A., et al.
Publicado: (2014)

A novel GJA8 mutation causing a recessive triangular cataract
por: Schmidt, Werner, et al.
Publicado: (2008)

First mitochondrial genome-wide association study with metabolomics
por: Aboulmaouahib, Brahim, et al.
Publicado: (2021)

A genome-wide analysis of DNA methylation identifies a novel association signal for Lp(a) concentrations in the LPA promoter
por: Coassin, Stefan, et al.
Publicado: (2020)

Genetic Variation in the Epidermal Transglutaminase Genes Is Not Associated with Atopic Dermatitis
por: Liedén, Agne, et al.
Publicado: (2012)

Genome-Wide Analysis of DNA Methylation and Fine Particulate Matter Air Pollution in Three Study Populations: KORA F3, KORA F4, and the Normative Aging Study
por: Panni, Tommaso, et al.
Publicado: (2016)

Anxiety Associated Increased CpG Methylation in the Promoter of Asb1: A Translational Approach Evidenced by Epidemiological and Clinical Studies and a Murine Model
por: Emeny, Rebecca T, et al.
Publicado: (2018)

Metabolomics profiling reveals novel markers for leukocyte telomere length
por: Zierer, Jonas, et al.
Publicado: (2016)

Mining the Unknown: A Systems Approach to Metabolite Identification Combining Genetic and Metabolic Information
por: Krumsiek, Jan, et al.
Publicado: (2012)

DeepWAS: Multivariate genotype-phenotype associations by directly integrating regulatory information using deep learning
por: Arloth, Janine, et al.
Publicado: (2020)

Metabolic Signatures Elucidate the Effect of Body Mass Index on Type 2 Diabetes
por: Dong, Qiuling, et al.
Publicado: (2023)

Gaussian graphical modeling reconstructs pathway reactions from high-throughput metabolomics data
por: Krumsiek, Jan, et al.
Publicado: (2011)

Common electrocardiogram measures are not associated with telomere length
por: von Falkenhausen, Aenne S., et al.
Publicado: (2022)

Mutation analysis in a German family identified a new cataract-causing allele in the CRYBB2 gene
por: Pauli, Silke, et al.
Publicado: (2007)

Body Fat Free Mass Is Associated with the Serum Metabolite Profile in a Population-Based Study
por: Jourdan, Carolin, et al.
Publicado: (2012)

Associations between thyroid hormones and serum metabolite profiles in an euthyroid population
por: Jourdan, Carolin, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_opqu1f6fcmscabbag2qisrq0du