A Simple High-Content Cell Cycle Assay Reveals Frequent Discrepancies between Cell Number and ATP and MTS Proliferation Assays

In order to efficiently characterize both antiproliferative potency and mechanism of action of small molecules targeting the cell cycle, we developed a high-throughput image-based assay to determine cell number and cell cycle phase distribution. Using this we profiled the effects of experimental and...

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Detalles Bibliográficos
Autores principales: Chan, Grace Ka Yan, Kleinheinz, Tracy L., Peterson, David, Moffat, John G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656927/
https://www.ncbi.nlm.nih.gov/pubmed/23691072
http://dx.doi.org/10.1371/journal.pone.0063583

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656927/
https://www.ncbi.nlm.nih.gov/pubmed/23691072
http://dx.doi.org/10.1371/journal.pone.0063583

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