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Comorbidities and Burden of COPD: A Population Based Case-Control Study

COPD is associated with a relevant burden of disease and a high mortality worldwide. Only recently, the importance of comorbidities of COPD has been recognized. Studies postulated an association with inflammatory conditions potentially sharing pathogenic pathways and worsening overall prognosis. Mor...

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Autores principales: Baty, Florent, Putora, Paul Martin, Isenring, Bruno, Blum, Torsten, Brutsche, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656944/
https://www.ncbi.nlm.nih.gov/pubmed/23691009
http://dx.doi.org/10.1371/journal.pone.0063285
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author Baty, Florent
Putora, Paul Martin
Isenring, Bruno
Blum, Torsten
Brutsche, Martin
author_facet Baty, Florent
Putora, Paul Martin
Isenring, Bruno
Blum, Torsten
Brutsche, Martin
author_sort Baty, Florent
collection PubMed
description COPD is associated with a relevant burden of disease and a high mortality worldwide. Only recently, the importance of comorbidities of COPD has been recognized. Studies postulated an association with inflammatory conditions potentially sharing pathogenic pathways and worsening overall prognosis. More evidence is required to estimate the role of comorbidities of COPD. Our aim was to investigate the prevalence and clustering of comorbidities associated with COPD, and to estimate their impact on clinically relevant outcomes. In this population-based case-control study, a nation-wide database provided by the Swiss Federal Office for Statistics enclosing every hospital entry covering the years 2002–2010 (n = 12′888′075) was analyzed using MySQL and R statistical software. Statistical methods included non-parametric hypothesis testing by means of Fisher’s exact test and Wilcoxon rank sum test, as well as linear models with generalized estimating equation to account for intra-patient variability. Exploratory multivariate approaches were also used for the identification of clusters of comorbidities in COPD patients. In 2.6% (6.3% in patients aged >70 years) of all hospitalization cases an active diagnosis of COPD was recorded. In 21% of these cases, COPD was the main reason for hospitalization. Patients with a diagnosis of COPD had more comorbidities (7 [IQR 4–9] vs. 3 [IQR 1–6]; [Image: see text]), were more frequently rehospitalized (annual hospitalization rate 0.33 [IQR 0.20–0.67] vs. 0.25 [IQR 0.14–0.43]/year; [Image: see text]), had a longer hospital stay (9 [IQR 4–15] vs. 5 [IQR 2–11] days; [Image: see text]), and had higher in-hospital mortality (5.9% [95% CI 5.8%–5.9%] vs. 3.4% [95% CI 3.3%–3.5%]; [Image: see text]) compared to matched controls. A set of comorbidities was associated with worse outcome. We could identify COPD-related clusters of COPD-comorbidities.
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spelling pubmed-36569442013-05-20 Comorbidities and Burden of COPD: A Population Based Case-Control Study Baty, Florent Putora, Paul Martin Isenring, Bruno Blum, Torsten Brutsche, Martin PLoS One Research Article COPD is associated with a relevant burden of disease and a high mortality worldwide. Only recently, the importance of comorbidities of COPD has been recognized. Studies postulated an association with inflammatory conditions potentially sharing pathogenic pathways and worsening overall prognosis. More evidence is required to estimate the role of comorbidities of COPD. Our aim was to investigate the prevalence and clustering of comorbidities associated with COPD, and to estimate their impact on clinically relevant outcomes. In this population-based case-control study, a nation-wide database provided by the Swiss Federal Office for Statistics enclosing every hospital entry covering the years 2002–2010 (n = 12′888′075) was analyzed using MySQL and R statistical software. Statistical methods included non-parametric hypothesis testing by means of Fisher’s exact test and Wilcoxon rank sum test, as well as linear models with generalized estimating equation to account for intra-patient variability. Exploratory multivariate approaches were also used for the identification of clusters of comorbidities in COPD patients. In 2.6% (6.3% in patients aged >70 years) of all hospitalization cases an active diagnosis of COPD was recorded. In 21% of these cases, COPD was the main reason for hospitalization. Patients with a diagnosis of COPD had more comorbidities (7 [IQR 4–9] vs. 3 [IQR 1–6]; [Image: see text]), were more frequently rehospitalized (annual hospitalization rate 0.33 [IQR 0.20–0.67] vs. 0.25 [IQR 0.14–0.43]/year; [Image: see text]), had a longer hospital stay (9 [IQR 4–15] vs. 5 [IQR 2–11] days; [Image: see text]), and had higher in-hospital mortality (5.9% [95% CI 5.8%–5.9%] vs. 3.4% [95% CI 3.3%–3.5%]; [Image: see text]) compared to matched controls. A set of comorbidities was associated with worse outcome. We could identify COPD-related clusters of COPD-comorbidities. Public Library of Science 2013-05-17 /pmc/articles/PMC3656944/ /pubmed/23691009 http://dx.doi.org/10.1371/journal.pone.0063285 Text en © 2013 Baty et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Baty, Florent
Putora, Paul Martin
Isenring, Bruno
Blum, Torsten
Brutsche, Martin
Comorbidities and Burden of COPD: A Population Based Case-Control Study
title Comorbidities and Burden of COPD: A Population Based Case-Control Study
title_full Comorbidities and Burden of COPD: A Population Based Case-Control Study
title_fullStr Comorbidities and Burden of COPD: A Population Based Case-Control Study
title_full_unstemmed Comorbidities and Burden of COPD: A Population Based Case-Control Study
title_short Comorbidities and Burden of COPD: A Population Based Case-Control Study
title_sort comorbidities and burden of copd: a population based case-control study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656944/
https://www.ncbi.nlm.nih.gov/pubmed/23691009
http://dx.doi.org/10.1371/journal.pone.0063285
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