Loading and activation of DNA replicative helicases: the key step of initiation of DNA replication

Evolution has led to diversification of all living organisms from a common ancestor. Consequently, all living organisms use a common method to duplicate their genetic information and thus pass on their inherited traits to their offspring. To duplicate chromosomal DNA, double-stranded DNA must first...

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Detalles Bibliográficos
Autores principales: Li, Yan, Araki, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657122/
https://www.ncbi.nlm.nih.gov/pubmed/23461534
http://dx.doi.org/10.1111/gtc.12040
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author Li, Yan
Araki, Hiroyuki
author_facet Li, Yan
Araki, Hiroyuki
author_sort Li, Yan
collection PubMed
description Evolution has led to diversification of all living organisms from a common ancestor. Consequently, all living organisms use a common method to duplicate their genetic information and thus pass on their inherited traits to their offspring. To duplicate chromosomal DNA, double-stranded DNA must first be unwound by helicase, which is loaded to replication origins and activated during the DNA replication initiation step. In this review, we discuss the common features of, and differences in, replicative helicases between prokaryotes and eukaryotes.
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spelling pubmed-36571222013-05-20 Loading and activation of DNA replicative helicases: the key step of initiation of DNA replication Li, Yan Araki, Hiroyuki Genes Cells Reviews Evolution has led to diversification of all living organisms from a common ancestor. Consequently, all living organisms use a common method to duplicate their genetic information and thus pass on their inherited traits to their offspring. To duplicate chromosomal DNA, double-stranded DNA must first be unwound by helicase, which is loaded to replication origins and activated during the DNA replication initiation step. In this review, we discuss the common features of, and differences in, replicative helicases between prokaryotes and eukaryotes. Blackwell Publishing Ltd 2013-04 2013-03-05 /pmc/articles/PMC3657122/ /pubmed/23461534 http://dx.doi.org/10.1111/gtc.12040 Text en Genes to Cells © 2013 by the Molecular Biology Society of Japan and Wiley Publishing Asia Pty Ltd http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle Reviews
Li, Yan
Araki, Hiroyuki
Loading and activation of DNA replicative helicases: the key step of initiation of DNA replication
title Loading and activation of DNA replicative helicases: the key step of initiation of DNA replication
title_full Loading and activation of DNA replicative helicases: the key step of initiation of DNA replication
title_fullStr Loading and activation of DNA replicative helicases: the key step of initiation of DNA replication
title_full_unstemmed Loading and activation of DNA replicative helicases: the key step of initiation of DNA replication
title_short Loading and activation of DNA replicative helicases: the key step of initiation of DNA replication
title_sort loading and activation of dna replicative helicases: the key step of initiation of dna replication
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657122/
https://www.ncbi.nlm.nih.gov/pubmed/23461534
http://dx.doi.org/10.1111/gtc.12040
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