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Avidity of influenza-specific memory CD8(+) T-cell populations decays over time compromising antiviral immunity

Decline of cell-mediated immunity is often attributed to decaying T-cell numbers and their distribution in peripheral organs. This study examined the hypothesis that qualitative as well as quantitative changes contribute to the declining efficacy of CD8(+) T-cell memory. Using a model of influenza v...

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Detalles Bibliográficos
Autores principales:	Humphreys, Ian R, Clement, Mathew, Marsden, Morgan, Ladell, Kristin, McLaren, James E, Smart, Kathryn, Hindley, James P, Bridgeman, Hayley M, van den Berg, Hugo A, Price, David A, Ager, Ann, Wooldridge, Linda, Godkin, Andrew, Gallimore, Awen M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2012
Materias:	Immunity to Infection
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657127/ https://www.ncbi.nlm.nih.gov/pubmed/22965681 http://dx.doi.org/10.1002/eji.201242575

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