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Mig6 Is a Sensor of EGF Receptor Inactivation that Directly Activates c-Abl to Induce Apoptosis during Epithelial Homeostasis

A fundamental aspect of epithelial homeostasis is the dependence on specific growth factors for cell survival, yet the underlying mechanisms remain obscure. We found an “inverse” mode of receptor tyrosine kinase signaling that directly links ErbB receptor inactivation to the induction of apoptosis....

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Detalles Bibliográficos
Autores principales:	Hopkins, Sarah, Linderoth, Emma, Hantschel, Oliver, Suarez-Henriques, Paula, Pilia, Giulia, Kendrick, Howard, Smalley, Matthew J., Superti-Furga, Giulio, Ferby, Ingvar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657149/ https://www.ncbi.nlm.nih.gov/pubmed/22975324 http://dx.doi.org/10.1016/j.devcel.2012.08.001

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