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IRS1 gene variants, dysglycaemic metabolic changes and type-2 diabetes risk

BACKGROUND AND AIMS: A recent genome-wide association study identified rs2943641C > T, 500 kb from the insulin receptor substrate-1 gene (IRS1), as a type-2 diabetes (T2D) susceptibility locus. We aimed to replicate this association by meta-analysis and examine whether common variants within IRS1...

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Detalles Bibliográficos
Autores principales:	Yiannakouris, N., Cooper, J.A., Shah, S., Drenos, F., Ireland, H.A., Stephens, J.W., Li, K.-W., Elkeles, R., Godsland, I.F., Kivimaki, M., Hingorani, A.D., Kumari, M., Talmud, P.J., Humphries, S.E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657179/ https://www.ncbi.nlm.nih.gov/pubmed/21917432 http://dx.doi.org/10.1016/j.numecd.2011.05.009

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