Early glial activation, synaptic changes and axonal pathology in the thalamocortical system of Niemann–Pick type C1 mice

Niemann–Pick disease type C (NPC) is an inherited lysosomal storage disease characterised by accumulation of cholesterol and glycosphingolipids. NPC patients suffer a progressive neurodegenerative phenotype presenting with motor dysfunction, mental retardation and cognitive decline. To examine the o...

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Detalles Bibliográficos
Autores principales: Pressey, Sarah N.R., Smith, David A., Wong, Andrew M.S., Platt, Frances M., Cooper, Jonathan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657200/
https://www.ncbi.nlm.nih.gov/pubmed/22198570
http://dx.doi.org/10.1016/j.nbd.2011.12.027

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