Perforating Dermatosis in a Patient Receiving Azathioprine

Azathioprine (AZA) is an imidazole derivative of mercaptopurine. It antagonizes purine metabolism, and it may inhibit synthesis of DNA, RNA, and proteins. The 6-thioguanine nucleotides appear to mediate the majority of AZAs immunosuppressive and toxic effects. While cutaneous adverse side-effects ar...

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Detalles Bibliográficos
Autores principales: Grillo, Emiliano, Vano-Galván, Sergio, Moreno, Carmen, Jaén, Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
E-Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657234/
https://www.ncbi.nlm.nih.gov/pubmed/23716824
http://dx.doi.org/10.4103/0019-5154.108077
Descripción
Sumario:Azathioprine (AZA) is an imidazole derivative of mercaptopurine. It antagonizes purine metabolism, and it may inhibit synthesis of DNA, RNA, and proteins. The 6-thioguanine nucleotides appear to mediate the majority of AZAs immunosuppressive and toxic effects. While cutaneous adverse side-effects are not uncommon, perforating dermatosis has not been reported in association to AZA. We speculate that immunological disorders induced by AZA in susceptible individuals could be related to perforating dermatosis.

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