Perforating Dermatosis in a Patient Receiving Azathioprine

Azathioprine (AZA) is an imidazole derivative of mercaptopurine. It antagonizes purine metabolism, and it may inhibit synthesis of DNA, RNA, and proteins. The 6-thioguanine nucleotides appear to mediate the majority of AZAs immunosuppressive and toxic effects. While cutaneous adverse side-effects ar...

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Autores principales: Grillo, Emiliano, Vano-Galván, Sergio, Moreno, Carmen, Jaén, Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
E-Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657234/
https://www.ncbi.nlm.nih.gov/pubmed/23716824
http://dx.doi.org/10.4103/0019-5154.108077
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author Grillo, Emiliano
Vano-Galván, Sergio
Moreno, Carmen
Jaén, Pedro
author_facet Grillo, Emiliano
Vano-Galván, Sergio
Moreno, Carmen
Jaén, Pedro
author_sort Grillo, Emiliano
collection PubMed
description Azathioprine (AZA) is an imidazole derivative of mercaptopurine. It antagonizes purine metabolism, and it may inhibit synthesis of DNA, RNA, and proteins. The 6-thioguanine nucleotides appear to mediate the majority of AZAs immunosuppressive and toxic effects. While cutaneous adverse side-effects are not uncommon, perforating dermatosis has not been reported in association to AZA. We speculate that immunological disorders induced by AZA in susceptible individuals could be related to perforating dermatosis.
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spelling pubmed-36572342013-05-28 Perforating Dermatosis in a Patient Receiving Azathioprine Grillo, Emiliano Vano-Galván, Sergio Moreno, Carmen Jaén, Pedro Indian J Dermatol E-Case Report Azathioprine (AZA) is an imidazole derivative of mercaptopurine. It antagonizes purine metabolism, and it may inhibit synthesis of DNA, RNA, and proteins. The 6-thioguanine nucleotides appear to mediate the majority of AZAs immunosuppressive and toxic effects. While cutaneous adverse side-effects are not uncommon, perforating dermatosis has not been reported in association to AZA. We speculate that immunological disorders induced by AZA in susceptible individuals could be related to perforating dermatosis. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3657234/ /pubmed/23716824 http://dx.doi.org/10.4103/0019-5154.108077 Text en Copyright: © Indian Journal of Dermatology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle E-Case Report
Grillo, Emiliano
Vano-Galván, Sergio
Moreno, Carmen
Jaén, Pedro
Perforating Dermatosis in a Patient Receiving Azathioprine
title Perforating Dermatosis in a Patient Receiving Azathioprine
title_full Perforating Dermatosis in a Patient Receiving Azathioprine
title_fullStr Perforating Dermatosis in a Patient Receiving Azathioprine
title_full_unstemmed Perforating Dermatosis in a Patient Receiving Azathioprine
title_short Perforating Dermatosis in a Patient Receiving Azathioprine
title_sort perforating dermatosis in a patient receiving azathioprine
topic E-Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657234/
https://www.ncbi.nlm.nih.gov/pubmed/23716824
http://dx.doi.org/10.4103/0019-5154.108077
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AT morenocarmen perforatingdermatosisinapatientreceivingazathioprine
AT jaenpedro perforatingdermatosisinapatientreceivingazathioprine

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