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2-Heptyl-Formononetin Increases Cholesterol and Induces Hepatic Steatosis in Mice
Consumption of isoflavones may prevent adiposity, hepatic steatosis, and dyslipidaemia. However, studies in the area are few and primarily with genistein. This study investigated the effects of formononetin and its synthetic analogue, 2-heptyl-formononetin (C7F), on lipid and cholesterol metabolism...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657407/ https://www.ncbi.nlm.nih.gov/pubmed/23738334 http://dx.doi.org/10.1155/2013/926942 |
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author | Andersen, Charlotte Schjoldager, Janne G. Tortzen, Christian G. Vegge, Andreas Hufeldt, Majbritt R. Skaanild, Mette T. Vogensen, Finn K. Kristiansen, Karsten Hansen, Axel K. Nielsen, John |
author_facet | Andersen, Charlotte Schjoldager, Janne G. Tortzen, Christian G. Vegge, Andreas Hufeldt, Majbritt R. Skaanild, Mette T. Vogensen, Finn K. Kristiansen, Karsten Hansen, Axel K. Nielsen, John |
author_sort | Andersen, Charlotte |
collection | PubMed |
description | Consumption of isoflavones may prevent adiposity, hepatic steatosis, and dyslipidaemia. However, studies in the area are few and primarily with genistein. This study investigated the effects of formononetin and its synthetic analogue, 2-heptyl-formononetin (C7F), on lipid and cholesterol metabolism in C57BL/6J mice. The mice were fed a cholesterol-enriched diet for five weeks to induce hypercholesterolemia and were then fed either the cholesterol-enriched diet or the cholesterol-enriched diet-supplemented formononetin or C7F for three weeks. Body weight and composition, glucose homeostasis, and plasma lipids were compared. In another experiment, mice were fed the above diets for five weeks, and hepatic triglyceride accumulation and gene expression and histology of adipose tissue and liver were examined. Supplementation with C7F increased plasma HDL-cholesterol thereby increasing the plasma level of total cholesterol. Supplementation with formononetin did not affect plasma cholesterol but increased plasma triglycerides levels. Supplementation with formononetin and C7F induced hepatic steatosis. However, formononetin decreased markers of inflammation and liver injury. The development of hepatic steatosis was associated with deregulated expression of hepatic genes involved in lipid and lipoprotein metabolism. In conclusion, supplementation with formononetin and C7F to a cholesterol-enriched diet adversely affected lipid and lipoprotein metabolism in C57BL/6J mice. |
format | Online Article Text |
id | pubmed-3657407 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-36574072013-06-04 2-Heptyl-Formononetin Increases Cholesterol and Induces Hepatic Steatosis in Mice Andersen, Charlotte Schjoldager, Janne G. Tortzen, Christian G. Vegge, Andreas Hufeldt, Majbritt R. Skaanild, Mette T. Vogensen, Finn K. Kristiansen, Karsten Hansen, Axel K. Nielsen, John Biomed Res Int Research Article Consumption of isoflavones may prevent adiposity, hepatic steatosis, and dyslipidaemia. However, studies in the area are few and primarily with genistein. This study investigated the effects of formononetin and its synthetic analogue, 2-heptyl-formononetin (C7F), on lipid and cholesterol metabolism in C57BL/6J mice. The mice were fed a cholesterol-enriched diet for five weeks to induce hypercholesterolemia and were then fed either the cholesterol-enriched diet or the cholesterol-enriched diet-supplemented formononetin or C7F for three weeks. Body weight and composition, glucose homeostasis, and plasma lipids were compared. In another experiment, mice were fed the above diets for five weeks, and hepatic triglyceride accumulation and gene expression and histology of adipose tissue and liver were examined. Supplementation with C7F increased plasma HDL-cholesterol thereby increasing the plasma level of total cholesterol. Supplementation with formononetin did not affect plasma cholesterol but increased plasma triglycerides levels. Supplementation with formononetin and C7F induced hepatic steatosis. However, formononetin decreased markers of inflammation and liver injury. The development of hepatic steatosis was associated with deregulated expression of hepatic genes involved in lipid and lipoprotein metabolism. In conclusion, supplementation with formononetin and C7F to a cholesterol-enriched diet adversely affected lipid and lipoprotein metabolism in C57BL/6J mice. Hindawi Publishing Corporation 2013 2013-04-29 /pmc/articles/PMC3657407/ /pubmed/23738334 http://dx.doi.org/10.1155/2013/926942 Text en Copyright © 2013 Charlotte Andersen et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Andersen, Charlotte Schjoldager, Janne G. Tortzen, Christian G. Vegge, Andreas Hufeldt, Majbritt R. Skaanild, Mette T. Vogensen, Finn K. Kristiansen, Karsten Hansen, Axel K. Nielsen, John 2-Heptyl-Formononetin Increases Cholesterol and Induces Hepatic Steatosis in Mice |
title | 2-Heptyl-Formononetin Increases Cholesterol and Induces Hepatic Steatosis in Mice |
title_full | 2-Heptyl-Formononetin Increases Cholesterol and Induces Hepatic Steatosis in Mice |
title_fullStr | 2-Heptyl-Formononetin Increases Cholesterol and Induces Hepatic Steatosis in Mice |
title_full_unstemmed | 2-Heptyl-Formononetin Increases Cholesterol and Induces Hepatic Steatosis in Mice |
title_short | 2-Heptyl-Formononetin Increases Cholesterol and Induces Hepatic Steatosis in Mice |
title_sort | 2-heptyl-formononetin increases cholesterol and induces hepatic steatosis in mice |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657407/ https://www.ncbi.nlm.nih.gov/pubmed/23738334 http://dx.doi.org/10.1155/2013/926942 |
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