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Preoperative Hematocrit Concentration and the Risk of Stroke in Patients Undergoing Isolated Coronary-Artery Bypass Grafting
Background. Identification and management of risk factors for stroke following isolated coronary artery bypass grafting (CABG) could potentially lower the risk of such serious morbidity. Methods. We retrieved data for 30-day stroke incidence and perioperative variables for patients undergoing isolat...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657438/ https://www.ncbi.nlm.nih.gov/pubmed/23738059 http://dx.doi.org/10.1155/2013/206829 |
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author | Musallam, Khaled M. Jamali, Faek R. Rosendaal, Frits R. Richards, Toby Spahn, Donat R. Khavandi, Kaivan Barakat, Iskandar Demoss, Benjamin Lotta, Luca A. Peyvandi, Flora Sfeir, Pier M. |
author_facet | Musallam, Khaled M. Jamali, Faek R. Rosendaal, Frits R. Richards, Toby Spahn, Donat R. Khavandi, Kaivan Barakat, Iskandar Demoss, Benjamin Lotta, Luca A. Peyvandi, Flora Sfeir, Pier M. |
author_sort | Musallam, Khaled M. |
collection | PubMed |
description | Background. Identification and management of risk factors for stroke following isolated coronary artery bypass grafting (CABG) could potentially lower the risk of such serious morbidity. Methods. We retrieved data for 30-day stroke incidence and perioperative variables for patients undergoing isolated CABG and used multivariate logistic regression to assess the adjusted effect of preoperative hematocrit concentration on stroke incidence. Results. In 2,313 patients (mean age 65.9 years, 73.6% men), 43 (1.9%, 95% CI: 1.4–2.5) developed stroke within 30 days following CABG (74.4% within 6 days). After adjustment for a priori defined potential confounders, each 1% drop in preoperative hematocrit concentration was associated with 1.07 (95% CI: 1.01–1.13) increased odds for stroke (men, OR: 1.08, 95% CI: 1.01–1.16; women, OR: 1.02, 95% CI: 0.91–1.16). The predicted probability of stroke for descending preoperative hematocrit concentration exceeded 2% for values <37% (<37% for men (adjusted OR: 2.39, 95% CI: 1.08–5.26) and <38% for women (adjusted OR: 2.52, 95% CI: 0.53–11.98), with a steeper probability increase noted in men). The association between lower preoperative hematocrit concentration and stroke was evident irrespective of intraoperative transfusion use. Conclusion. Screening and management of patients with low preoperative hematocrit concentration may alter postoperative stroke risk in patients undergoing isolated CABG. |
format | Online Article Text |
id | pubmed-3657438 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-36574382013-06-04 Preoperative Hematocrit Concentration and the Risk of Stroke in Patients Undergoing Isolated Coronary-Artery Bypass Grafting Musallam, Khaled M. Jamali, Faek R. Rosendaal, Frits R. Richards, Toby Spahn, Donat R. Khavandi, Kaivan Barakat, Iskandar Demoss, Benjamin Lotta, Luca A. Peyvandi, Flora Sfeir, Pier M. Anemia Research Article Background. Identification and management of risk factors for stroke following isolated coronary artery bypass grafting (CABG) could potentially lower the risk of such serious morbidity. Methods. We retrieved data for 30-day stroke incidence and perioperative variables for patients undergoing isolated CABG and used multivariate logistic regression to assess the adjusted effect of preoperative hematocrit concentration on stroke incidence. Results. In 2,313 patients (mean age 65.9 years, 73.6% men), 43 (1.9%, 95% CI: 1.4–2.5) developed stroke within 30 days following CABG (74.4% within 6 days). After adjustment for a priori defined potential confounders, each 1% drop in preoperative hematocrit concentration was associated with 1.07 (95% CI: 1.01–1.13) increased odds for stroke (men, OR: 1.08, 95% CI: 1.01–1.16; women, OR: 1.02, 95% CI: 0.91–1.16). The predicted probability of stroke for descending preoperative hematocrit concentration exceeded 2% for values <37% (<37% for men (adjusted OR: 2.39, 95% CI: 1.08–5.26) and <38% for women (adjusted OR: 2.52, 95% CI: 0.53–11.98), with a steeper probability increase noted in men). The association between lower preoperative hematocrit concentration and stroke was evident irrespective of intraoperative transfusion use. Conclusion. Screening and management of patients with low preoperative hematocrit concentration may alter postoperative stroke risk in patients undergoing isolated CABG. Hindawi Publishing Corporation 2013 2013-04-30 /pmc/articles/PMC3657438/ /pubmed/23738059 http://dx.doi.org/10.1155/2013/206829 Text en Copyright © 2013 Khaled M. Musallam et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Musallam, Khaled M. Jamali, Faek R. Rosendaal, Frits R. Richards, Toby Spahn, Donat R. Khavandi, Kaivan Barakat, Iskandar Demoss, Benjamin Lotta, Luca A. Peyvandi, Flora Sfeir, Pier M. Preoperative Hematocrit Concentration and the Risk of Stroke in Patients Undergoing Isolated Coronary-Artery Bypass Grafting |
title | Preoperative Hematocrit Concentration and the Risk of Stroke in Patients Undergoing Isolated Coronary-Artery Bypass Grafting |
title_full | Preoperative Hematocrit Concentration and the Risk of Stroke in Patients Undergoing Isolated Coronary-Artery Bypass Grafting |
title_fullStr | Preoperative Hematocrit Concentration and the Risk of Stroke in Patients Undergoing Isolated Coronary-Artery Bypass Grafting |
title_full_unstemmed | Preoperative Hematocrit Concentration and the Risk of Stroke in Patients Undergoing Isolated Coronary-Artery Bypass Grafting |
title_short | Preoperative Hematocrit Concentration and the Risk of Stroke in Patients Undergoing Isolated Coronary-Artery Bypass Grafting |
title_sort | preoperative hematocrit concentration and the risk of stroke in patients undergoing isolated coronary-artery bypass grafting |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657438/ https://www.ncbi.nlm.nih.gov/pubmed/23738059 http://dx.doi.org/10.1155/2013/206829 |
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