Age-Dependent Accumulation of 8-Oxoguanine in the DNA and RNA in Various Rat Tissues

The relationship between the oxidative damage of nucleic acids and aging of animals was investigated by analyzing the nucleic acids derived from various tissue specimens of naturally aged Sprague-Dawley (SD) rats. For this purpose, we established an accurate and sensitive isotope-diluted LC-MS/MS me...

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Detalles Bibliográficos
Autores principales: Nie, Ben, Gan, Wei, Shi, Fei, Hu, Guo-Xin, Chen, Lian-Guo, Hayakawa, Hiroshi, Sekiguchi, Mutsuo, Cai, Jian-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657452/
https://www.ncbi.nlm.nih.gov/pubmed/23738036
http://dx.doi.org/10.1155/2013/303181

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657452/
https://www.ncbi.nlm.nih.gov/pubmed/23738036
http://dx.doi.org/10.1155/2013/303181

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