Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles

Targeting noncatalytic cysteine residues with irreversible acrylamide-based inhibitors is a powerful approach for enhancing pharmacological potency and selectivity. Nevertheless, concerns about off-target modification motivate the development of reversible cysteine-targeting strategies. Here we show...

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Detalles Bibliográficos
Autores principales: Serafimova, Iana M., Pufall, Miles A., Krishnan, Shyam, Duda, Katarzyna, Cohen, Michael S., Maglathlin, Rebecca L., McFarland, Jesse M., Miller, Rand M., Frödin, Morten, Taunton, Jack
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657615/
https://www.ncbi.nlm.nih.gov/pubmed/22466421
http://dx.doi.org/10.1038/nchembio.925

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657615/
https://www.ncbi.nlm.nih.gov/pubmed/22466421
http://dx.doi.org/10.1038/nchembio.925

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