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T Cell Aging: A Review of the Transcriptional Changes Determined from Genome-Wide Analysis

Age carries a detrimental impact on T cell function. In the past decade, analyses of the genome-scale transcriptional changes of T cells during aging have yielded a large amount of data and provided a global view of gene expression changes in T cells from aged hosts as well as subsets of T cells acc...

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Detalles Bibliográficos
Autores principales: Chen, Guobing, Lustig, Ana, Weng, Nan-ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657702/
https://www.ncbi.nlm.nih.gov/pubmed/23730304
http://dx.doi.org/10.3389/fimmu.2013.00121
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author Chen, Guobing
Lustig, Ana
Weng, Nan-ping
author_facet Chen, Guobing
Lustig, Ana
Weng, Nan-ping
author_sort Chen, Guobing
collection PubMed
description Age carries a detrimental impact on T cell function. In the past decade, analyses of the genome-scale transcriptional changes of T cells during aging have yielded a large amount of data and provided a global view of gene expression changes in T cells from aged hosts as well as subsets of T cells accumulated with age. Here, we aim to review the changes of gene expression in thymocytes and peripheral mature T cells, as well as the subsets of T cells accumulated with age, and discuss the gene networks and signaling pathways that are altered with aging in T cells. We also discuss future direction for furthering the understanding of the molecular basis of gene expression alterations in aged T cells, which could potentially provide opportunities for gene-based clinical interventions.
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spelling pubmed-36577022013-05-31 T Cell Aging: A Review of the Transcriptional Changes Determined from Genome-Wide Analysis Chen, Guobing Lustig, Ana Weng, Nan-ping Front Immunol Immunology Age carries a detrimental impact on T cell function. In the past decade, analyses of the genome-scale transcriptional changes of T cells during aging have yielded a large amount of data and provided a global view of gene expression changes in T cells from aged hosts as well as subsets of T cells accumulated with age. Here, we aim to review the changes of gene expression in thymocytes and peripheral mature T cells, as well as the subsets of T cells accumulated with age, and discuss the gene networks and signaling pathways that are altered with aging in T cells. We also discuss future direction for furthering the understanding of the molecular basis of gene expression alterations in aged T cells, which could potentially provide opportunities for gene-based clinical interventions. Frontiers Media S.A. 2013-05-20 /pmc/articles/PMC3657702/ /pubmed/23730304 http://dx.doi.org/10.3389/fimmu.2013.00121 Text en Copyright © 2013 Chen, Lustig and Weng. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Immunology
Chen, Guobing
Lustig, Ana
Weng, Nan-ping
T Cell Aging: A Review of the Transcriptional Changes Determined from Genome-Wide Analysis
title T Cell Aging: A Review of the Transcriptional Changes Determined from Genome-Wide Analysis
title_full T Cell Aging: A Review of the Transcriptional Changes Determined from Genome-Wide Analysis
title_fullStr T Cell Aging: A Review of the Transcriptional Changes Determined from Genome-Wide Analysis
title_full_unstemmed T Cell Aging: A Review of the Transcriptional Changes Determined from Genome-Wide Analysis
title_short T Cell Aging: A Review of the Transcriptional Changes Determined from Genome-Wide Analysis
title_sort t cell aging: a review of the transcriptional changes determined from genome-wide analysis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657702/
https://www.ncbi.nlm.nih.gov/pubmed/23730304
http://dx.doi.org/10.3389/fimmu.2013.00121
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