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Evaluation of a programme for prevention of vertical transmission of hepatitis B in a rural block in southern India

BACKGROUND & OBJECTIVES: This study was undertaken to evaluate a community based programme of antenatal screening for hepatitis B surface antigen (HBsAg) and selective immunization of children commencing at birth, at a secondary care hospital in south India. The primary objective was to assess i...

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Autores principales: Alexander, Anu Mary, Prasad, Jasmin Helen, Abraham, Priya, Fletcher, John, Muliyil, Jayaprakash, Balraj, Vinohar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657860/
https://www.ncbi.nlm.nih.gov/pubmed/23563380
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author Alexander, Anu Mary
Prasad, Jasmin Helen
Abraham, Priya
Fletcher, John
Muliyil, Jayaprakash
Balraj, Vinohar
author_facet Alexander, Anu Mary
Prasad, Jasmin Helen
Abraham, Priya
Fletcher, John
Muliyil, Jayaprakash
Balraj, Vinohar
author_sort Alexander, Anu Mary
collection PubMed
description BACKGROUND & OBJECTIVES: This study was undertaken to evaluate a community based programme of antenatal screening for hepatitis B surface antigen (HBsAg) and selective immunization of children commencing at birth, at a secondary care hospital in south India. The primary objective was to assess immunization coverage among children born to HBsAg positive women; secondary objectives were to study the prevalence of HBsAg among antenatal women, prevalence of HBsAg among immunized children (to estimate vaccine efficacy), seroconversion rate and relationship of maternal hepatitis B e antigen (HBeAg) to hepatitis infection. METHODS: The prevalence of hepatitis B antigen among antenatal women and immunization coverage achieved with hepatitis B vaccine in a rural block in Vellore, Tamil Nadu were assessed through examination of records. Children born between May 2002 and December 2007 to hepatitis B positive women were followed up for a serological evaluation, based on which vaccine efficacy and the effect of maternal hepatitis B e antigen (HBeAg) on breakthrough infection was estimated. RESULTS: The prevalence of hepatitis B surface antigen among antenatal women was 1.58 % (95% CI: 1.35-1.81%). Vaccine coverage for three doses as per a recommended schedule (including a birth dose) was 70 per cent, while 82.4 per cent eventually received three doses (including a birth dose). Estimated vaccine efficacy was 68 per cent and seroconversion 92.4 per cent in children aged 6-24 months. Maternal HBeAg was significantly associated with either anti-HBc or HBsAg in immunized children, RR=5.89 (95% CI: 1.21-28.52%). INTERPRETATION & CONCLUSIONS: The prevalence of hepatitis B among antenatal women in this region was low and a programme of selective immunization was found to be feasible, achieving a high coverage for three doses of the vaccine including a birth dose.
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spelling pubmed-36578602013-05-28 Evaluation of a programme for prevention of vertical transmission of hepatitis B in a rural block in southern India Alexander, Anu Mary Prasad, Jasmin Helen Abraham, Priya Fletcher, John Muliyil, Jayaprakash Balraj, Vinohar Indian J Med Res Original Article BACKGROUND & OBJECTIVES: This study was undertaken to evaluate a community based programme of antenatal screening for hepatitis B surface antigen (HBsAg) and selective immunization of children commencing at birth, at a secondary care hospital in south India. The primary objective was to assess immunization coverage among children born to HBsAg positive women; secondary objectives were to study the prevalence of HBsAg among antenatal women, prevalence of HBsAg among immunized children (to estimate vaccine efficacy), seroconversion rate and relationship of maternal hepatitis B e antigen (HBeAg) to hepatitis infection. METHODS: The prevalence of hepatitis B antigen among antenatal women and immunization coverage achieved with hepatitis B vaccine in a rural block in Vellore, Tamil Nadu were assessed through examination of records. Children born between May 2002 and December 2007 to hepatitis B positive women were followed up for a serological evaluation, based on which vaccine efficacy and the effect of maternal hepatitis B e antigen (HBeAg) on breakthrough infection was estimated. RESULTS: The prevalence of hepatitis B surface antigen among antenatal women was 1.58 % (95% CI: 1.35-1.81%). Vaccine coverage for three doses as per a recommended schedule (including a birth dose) was 70 per cent, while 82.4 per cent eventually received three doses (including a birth dose). Estimated vaccine efficacy was 68 per cent and seroconversion 92.4 per cent in children aged 6-24 months. Maternal HBeAg was significantly associated with either anti-HBc or HBsAg in immunized children, RR=5.89 (95% CI: 1.21-28.52%). INTERPRETATION & CONCLUSIONS: The prevalence of hepatitis B among antenatal women in this region was low and a programme of selective immunization was found to be feasible, achieving a high coverage for three doses of the vaccine including a birth dose. Medknow Publications & Media Pvt Ltd 2013-02 /pmc/articles/PMC3657860/ /pubmed/23563380 Text en Copyright: © The Indian Journal of Medical Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Alexander, Anu Mary
Prasad, Jasmin Helen
Abraham, Priya
Fletcher, John
Muliyil, Jayaprakash
Balraj, Vinohar
Evaluation of a programme for prevention of vertical transmission of hepatitis B in a rural block in southern India
title Evaluation of a programme for prevention of vertical transmission of hepatitis B in a rural block in southern India
title_full Evaluation of a programme for prevention of vertical transmission of hepatitis B in a rural block in southern India
title_fullStr Evaluation of a programme for prevention of vertical transmission of hepatitis B in a rural block in southern India
title_full_unstemmed Evaluation of a programme for prevention of vertical transmission of hepatitis B in a rural block in southern India
title_short Evaluation of a programme for prevention of vertical transmission of hepatitis B in a rural block in southern India
title_sort evaluation of a programme for prevention of vertical transmission of hepatitis b in a rural block in southern india
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657860/
https://www.ncbi.nlm.nih.gov/pubmed/23563380
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